Hedgehog信号通路在肾纤维化中的研究进展

Research progress of Hedgehog signaling pathway in renal fibrosis

肾纤维化是大多数慢性肾脏病(CKD)的共同病理表现,也是导致终末期肾病的主要病理变化。近年研究发现,Hedgehog(Hh)信号通路在肾纤维化中起重要作用。此通路区别于以往研究较多的TGF-β及Wnt通路等,其激活主要直接靶向作用于肾纤维化发生的中心事件——肌成纤维细胞的活化、增殖与转化,暗示此通路在肾纤维化发生过程中起极为重要作用,而此通路与其他通路相互作用亦促进肾纤维化发生发展。深入对此通路的研究可能为治疗肾纤维化提供新思路。文章就Hh信号通路与肾纤维化的关系进行综述。

Renal fibrosis is a common pathological manifestation of most chronic kidney disease(CKD)and a major pathological change leading to end-stage renal disease.Recent studies have found that the Hedgehog(Hh)signaling pathway plays an important role in renal fibrosis.This pathway is different from the TGF-βand Wnt pathways that have been studied in the past.Its activation mainly directly targets the central event of renal fibrosis-activation,proliferation and transformation of myofibroblasts.It suggests that this pathway plays an important role in the process of renal fibrosis,and this pathway interacts with other pathways to promote the development of renal fibrosis.Further research into this pathway may provide new ideas for the treatment of renal fibrosis.This article reviews the relationship between Hh signaling pathway and renal fibrosis.