赖氨酸羟化酶2在肿瘤转移中的研究进展

The role and research progress of PLOD2 in tumor metastasis

肿瘤侵袭和转移是导致肿瘤患者不良预后的主要因素。近年来研究发现,细胞外基质中胶原纤维重构能够促进肿瘤的侵袭与转移。赖氨酸羟化酶2(PLOD2)是唯一可改变胶原纤维交联和重构模式的赖氨酸羟化酶,其在多种肿瘤中高表达,且与肿瘤侵袭和转移密切相关,因此,深入研究PLOD2在肿瘤转移中的作用及机制,对于判断肿瘤预后转归及防治肿瘤侵袭和转移具有重要的科学价值。文章主要就PLOD2在肿瘤侵袭和转移中的作用及潜在机制的相关研究进展进行综述。

Tumor invasion and metastasis are the main factors leading to poor prognosis of cancer patients.In recent years,studies have found that collagen fiber remodeling in extracellular matrix(ECM)can promote tumor invasion and metastasis.Lysine hydroxylase 2(PLOD2)is the only lysine hydroxylase that changes the pattern of collagen fiber cross-linking and remodeling.It is highly expressed in many tumors and is closely related to tumor invasion and metastasis,Therefore,in-depth study of the role and mechanism of PLOD2 in tumor metastasis is of great scientific value for judging tumor prognosis and preventing tumor invasion and metastasis.This article reviews the recent advances in the role and potential mechanisms of PLOD2 in tumor invasion and metastasis.