汉防己甲素对尘肺患者的免疫功能及肺通气功能的影响

Effect of tetrandrine on immune function and pulmonary ventilation function in patients with pneumoconiosis

目的对尘肺患者应用汉防己甲素治疗,以此评价汉防己甲素治疗后对免疫功能、肺通气功能的影响。方法选取时间于2017年8月-2018年8月尘肺患者共计100例作为研究对象。以汉防己甲素治疗、矽肺宁治疗分为研究组、对照组。经系统软件处理和分析组间的IL-1、TNA-a、FVC、FEV1、FEV1/FVC、生存率数据指标。结果研究组的TNA-a(38.99±10.07 pg/ml)、FVC(0.87±0.02 L)、FEV1(1.99±0.37 L)、FEV1/FVC(80.09±8.11%)、生存率(96.00%)经系统软件处理和分析发现均高于对照组,且研究组的IL-1(57.77±17.77 pg/ml)低于对照组(73.33±10.09 pg/ml),P<0.05,差异显著。结论对尘肺患者予以汉防己甲素治疗,可以有效改善患者的免疫功能、肺通气功能,从而提高患者的生存率,以此能够获得更为显著的临床治疗效果。

Objective To evaluate the effect of tetrandrine on immune function and pulmonary ventilation function in patients with pneumoconiosis.Methods A total of 100 pneumoconiosis patients from August 2017 to August 2018 were selected as the study subjects.Tetrandrine and Siliconin were divided into the study group and the control group.The data of IL-1,TNA-a,FVC,FEV1,FEV1/FVC and survival rate were processed and analyzed by system software.Results TNA-a(38.99+10.07 pg/ml),FVC(0.87+0.02 L),FEV1(1.99+0.37 L),FEV1/FVC(80.09+8.11%)and survival rate(96.00%)in the study group were higher than that of the control group,and IL-1(57.77+17.77 pg/ml)in the study group was lower than that of the control group(73.33+10.09 pg/ml),P<0.05,with significant difference.Conclusion Tetrandrine treatment can effectively improve the immune function and pulmonary ventilation function of patients with pneumoconiosis,thereby improving the survival rate of patients,so as to obtain more significant clinical therapeutic effect.