卒中后抑郁相关危险因素及其机制

Discuss the Risk Factors and Mechanism of Post-stroke Depression

脑卒中是临床常见疾病,具有明显的高发病率、高致残率及高死亡率。卒中后抑郁(post-stroke depression,PSD)是其最常见的并发症之一。它不仅增加了患者及家属精神上的痛苦,也影响脑卒中的康复及预后。PSD的发病率很高,但在临床上有很容易被忽视。该文对目前有研究的PSD相关危险因素(脑供血动脉病变;下丘脑-垂体-肾上腺轴(HPA轴)功能变化;血尿酸水平;同型半胱氨酸水平;血清超敏C反应蛋白(hs-CRP)水平等,及其机制进行阐述,旨在为PSD的早期诊治提供帮助,有利于卒中的康复及预后。

Stroke is a common clinical disease with high morbidity,disability and mortality.Post-stroke depression(PSD)is one of the most common complications of stroke.It not only increases the mental pain of patients and their families,but also prevents the rehabilitation and prognosis of stroke.The incidence of PSD is high,but it is easy to be ignored in clinic.In this paper,the risk factors related to PSD(cerebral artery disease;hypothalamic-pituitary adrenal axis(HPA axis)function changes;serum uric acid level;homocysteine level;serum hs-CRP level)and their mechanisms were reviewed.The aim is to provide help for the early diagnosis and treatment of PSD,and to facilitate the rehabilitation and prognosis of stroke.