甲状腺功能减退症患者其甲状腺功能与血脂的相关性分析

Analysis of the correlation between thyroid function and blood lipid in patients with hypothyroidism

目的 观察分析甲状腺功能减退症患者的血脂水平以及血脂在临床中的研究意义。方法 选取本院(在 2016 年 1 月- 2019 年 2 月)搜集的 67 例甲状腺功能减退症患者一般资料作为实验组,再选取同期我院收治的 67 例健康体检者一般资料作为对照组。采用统计学分析两组研究对象的血脂水平[TG(甘油三酯)、HDL-C(高密度脂蛋白胆固醇)、LDL-C(低密度 脂蛋白胆固醇)等水平],分析 FT3(血清游离三碘甲状腺原氨酸)、FT4(游离甲状腺素)、TSH(促甲状腺激素)与血脂之间的相 关性。结果 两组研究对象的甘油三酯水平比较无差异性(P > 0.05),实验组的高密度脂蛋白胆固胆固醇水平、血清游离三碘甲 状腺原氨酸水平、游离甲状腺素水平低于对照组(P < 0.05),实验组的低密度脂蛋白胆固醇、促甲状腺激素等各项血脂水平显著高于对照组(P < 0.05);血清游离三碘甲状腺原氨酸水平与甘油三酯水平、高密度脂蛋白胆固胆固醇水平、低密度脂蛋白胆 固醇水平呈负相关(P < 0.05),游离甲状腺素水平与甘油三酯水平、高密度脂蛋白胆固胆固醇水平、低密度脂蛋白胆固醇水平 呈负相关(P <0.05),促甲状腺激素水平与甘油三酯水平、高密度脂蛋白胆固胆固醇水平、低密度脂蛋白胆固醇水平呈正相关 (P < 0.05)。结论 甲状腺功能减退症患者的血脂水平比较高,血脂水平与甲状腺功能减退症患者有较强相关性。

Objective To observe and analyze the level of blood lipid in patients with hypothyroidism and the significance of bloodlipid in clinical research. Methods 67 patients with hypothyroidism collected in our hospital from January 2016 to February 2019 wereselected as the experimental group, and 67 patients with health examination admitted in our hospital during the same period were selectedas the control group. The serum lipid levels [TG (triglyceride), HDL- C (high density lipoprotein cholesterol), LDL- C (low densitylipoprotein cholesterol) and so on] of the two groups were analyzed by statistics, and the correlation between FT3 (serum freetriiodothyronine), FT4 (free thyroxine), TSH (thyroid stimulating hormone)and blood lipid was analyzed. Results There was nosignificant difference in triglyceride level between the two groups (P > 0.05). The levels of HDL cholesterol, serum free triiodothyronineand free thyroxine in the experimental group were lower than that of the control group (P < 0.05). The levels of LDL cholesterol,thyrotropin and other blood lipids in the experimental group were significantly higher than that of the control group (P < 0.05). Serum freetriiodothyronine level was negatively correlated with triglyceride level, high density lipoprotein cholesterol level and low density lipoproteincholesterol level(P < 0.05). Free thyroxine level was negatively correlated with triglyceride level, high density lipoprotein cholesterol leveland low density lipoprotein cholesterol level(P < 0.05), and thyrotropin level was negatively correlated with triglyceride level, high densitylipoprotein cholesterol level and low density lipoprotein cholesterol level (P < 0.05). The levels of triglyceride, high density lipoproteincholesterol and low density lipoprotein cholesterol were positively correlated (P < 0.05). Conclusion The level of blood lipid in patientswith hypothyroidism is relatively high, and there is a strong correlation between the level of blood lipid and patients with hypothyroidism.