卡维地洛联合尼可地尔对冠心病患者的临床疗效分析

Analysis of clinical efficacy of carvedilol combined with nicorandil in patients with coronary heart disease

目的 探讨分析卡维地洛与尼可地尔联合治疗冠心病的临床疗效.方法 40例冠心病患者,随机分为对照组和治疗组,各20例.对照组患者住院后常规使用卡维地洛治疗,治疗组患者在对照组基础上联用尼可地尔治疗.比较两组患者疗效、心电图指标(ST段压低次数、心肌缺血总负荷、ST段压低总持续时间)水平、不良反应发生情况.结果 治疗组患者的治疗总有效率95.0% 显著高于对照组的65.0%,差异具有统计学意义(P<0.05).治疗后,两组患者的ST段压低次数和心肌缺血总负荷均低于治疗前、ST段压低总持续时间短于治疗前,且治疗组患者的ST段压低次数和心肌缺血总负荷均低于对照组、ST段压低总持续时间短于对照组,差异均具有统计学意义(P<0.05).治疗组患者的不良反应发生率为10.0%,显著低于对照组的40.0%,差异具有统计学意义(P<0.05).结论 卡维地洛联合尼可地尔治疗冠心病效果显著,可改善患者的心功能指标,降低不良反应发生率,在临床中具有广泛的应用价值.

Objective To discuss and analyze the clinical efficacy of carvedilol combined with nicorandil in patients with coronary heart disease.Methods A total of 40 patients with coronary heart disease were randomly divided into control group and treatment group,with 20 cases in each group.Patients in the control group were treated with carvedilol routinely after hospitalization,while patients in the treatment group were treated with nicorandil on the basis of the control group.Comparison was made on efficacy,electrocardiogram indicators(number of ST-segment depression,total myocardial ischemic load,total duration of ST-segment depression)and occurrence of adverser reactions between the two groups.Results The total effective rate of treatment was 95.0%,which was significantly higher than 65.0%in the control group,and the difference was statistically significant(P<0.05).After treatment,the number of ST-segment depression and total myocardial ischemic load in two groups were lower than those before treatment,and total duration of ST-segment depression was shorter than those before treatment.The number of ST-segment depression and total myocardial ischemic load in the treatment group were lower than those in the control group,and total duration of ST-segment depression was shorter than that in the control group.Their difference was statistically significant(P<0.05).The incidence of adverse reactions was 10.0%in the treatment,which was significantly lower than 40.0%in the control group,and the difference was statistically significant(P<0.05).Conclusion Carvedilol combined with nicorandil has a significant effect in the treatment of coronary heart disease,and it can improve patients’cardiac function indicators,reduce the incidence of adverse reactions.It contains a wide range of clinical application value.