放疗联合肝动脉栓塞化疗治疗大肠癌肝转移的疗效探讨

Therapeutic Effect of Radiotherapy Combined with Transcatheter Arterial Chemoembolization on Liver Metastasis of Colorectal Cancer

目的探讨放疗联合肝动脉栓塞化疗治疗大肠癌肝转移的疗效。方法方便选择2017年7月—2018年9月治疗大肠癌肝转移患者50例作为该次研究对象,随机数字表将50例患者分为对照组(n=25)与观察组(n=25)。对照组患者采用常规TACE治疗,观察组患者给予放疗联合肝动脉栓塞化疗法,15 d后对患者疗效及并发症发生率进行评估,比较两组患者治疗前后治疗效果以及并发症发生率。结果观察组治疗后疗效率为96.00%,高于对照组84.00%(χ^2=6.396,P=0.024),观察组与对照组患者在治疗后白细胞减少、腹泻、腹痛、手足综合征、恶心、呕吐的发生率比较,差异无统计学意义(χ^2=0.430、0.170、0.170、0.130,P=0.710、0.690、0.690、0.710)。结论将放疗联合肝动脉栓塞化疗治疗应用大肠癌肝转移患者的治疗当中,治疗效果好且不会更加不良反应的发生率,值得推广应用。

Objective To investigate the efficacy of radiotherapy combined with transcatheter arterial chemoembolization in the treatment of colorectal cancer with liver metastasis.Methods A total of 50 patients with colorectal cancer liver metastases from July 2017 to September 2018 were convenient selected and enrolled.The randomized digital table divided 50 patients into control group(n=25)and observation group(n=25).Patients in the control group were treated with conventional TACE.Patients in the observation group were treated with radiotherapy combined with hepatic artery embolization.The efficacy and complication rate of the patients were evaluated on the 15th day.The treatment effect and the incidence of complications were compared before and after treatment.Results The therapeutic effect rate of the observation group was 96.00%,which was higher than that of the control group(84.00%)(χ^2=6.396,P=0.024).The patients in the observation group and the control group had leukopenia,diarrhea,abdominal pain,hand-foot syndrome,nausea and vomiting after treatment.The incidence was not statistically significant(χ^2=0.430,0.170,0.170,0.130,P=0.710,0.690,0.690,0.710).Conclusion Radiotherapy combined with transcatheter arterial chemoembolization for the treatment of patients with liver metastases from colorectal cancer has a good therapeutic effect and no more adverse reactions.It is worthy of popularization and application.