调查分析慢阻肺患者急性加重期抗菌药物的合理性应用

Investigation and Analysis of the Rational Application of Antibiotics in Patients with Chronic Obstructive Pulmonary Disease during Acute Exacerbation

目的调查分析慢阻肺患者急性加重期抗菌药物的合理性应用。方法以2018年1—12月期间该院主要治疗的慢阻肺急性加重期患者的病例为临床研究资料,对患者的基本资料、抗菌药物使用情况以及基本检查情况进行了解。分别评价患者的疗效情况与用药的合理性。结果200例患者均使用抗菌药物进行治疗,以氨曲南粉针、左氧氟沙星、异帕米星等药物的使用频率较高,均在20.00%以上;患者治疗总有效率为89.00%。11.00%的患者出现不良反应,主要表现有皮肤瘙痒、手抖、心慌、出血性胃炎,而氨溟索注射液、沙丁胺醇、氨茶碱注射液、地塞米松磷酸钠注射液等为主要的不良反应药物;合理用药者占86.50%,不合理用药的主要原因有选药不合理、用量与疗程不合理以及联合用药不合理。结论慢性阻塞性肺疾病患者处在急性加重期合理使用抗菌药物进行治疗,不仅可以改善患者各项指标,也能降低不良反应发生率,且效果明显比传统药物好。而医院医务人员及药师应重点加强对抗菌药物的药学监护,提高用药的合理性和安全性。

Objective To investigate the rational application of antibiotics in patients with chronic obstructive pulmonary disease during acute exacerbation.Methods The clinical data of patients with acute exacerbation of chronic obstructive pulmonary disease who were mainly treated in the hospital from January to December 2018,were used as basic clinical data,antibiotic use and basic examination.The patient's efficacy and rationality of the medication were evaluated separately.Results All the 200 patients were treated with antibiotics.The frequency of arrhizin,levofloxacin,and isopamicin was higher than 20.00%.The total effective rate of patients was 89.00%.11.00% of patients had adverse reactions,mainly including skin itching,hand tremor,palpitation,hemorrhagic gastritis,and ampicillin injection,salbutamol,aminophylline injection,dexamethasone sodium phosphate injection,etc.reactive drugs;86.5%of the rational drug use,the main reasons for irrational drug use are unreasonable drug selection,unreasonable dosage and treatment.Conclusion Patients with chronic obstructive pulmonary disease who are treated with antibiotics in the acute exacerbation period can not only improve the indicators of patients,but also reduce the incidence of adverse reactions,and the effect is better than traditional drugs.The hospital medical staff and pharmacists should focus on strengthening the pharmaceutical supervision of antibacterial drugs and improving the rationality and safety of the drugs.