血清C反应蛋白与慢性阻塞性肺疾病急性加重期预后的关系研究

Study on the relationship between serum C-reactive protein and prognosis of acute exacerbation of chronic obstructive pulmonary disease

目的探析应用血清C反应蛋白监测慢性阻塞性肺疾病急性加重期(AECOPD)的临床价值。方法选取本院于2014年7月至2018年4月收治的72例AECOPD患者作为实验组,并将同期收治来院进行体检的72名健康者作为对照组。对两组患者治疗前后的血清中CRP、红细胞沉降率(ESR)、中性粒细胞计数(NC)以及白细胞计数(WBC)水平,进行分析对比。结果实验组患者血清中CRP、ESR、NC以及WBC水平均显著高于对照组,两组比较差异具有统计学意义(P<0.05);AECOPD患者可随着病情的加重,血清CRP水平随之升高,其中轻度组、中度组、重度组以及极重度组AECPDO患者之间血清CRP水平相较差异具有统计学意义(P<0.05)。结论AECOPD患者血清CRP水平可准确反映其肺部感染的严重程度,同时在治疗期间运用血清CRP水平监测其变化,能充分反映其治疗效果,对患者的治疗有较高的指导价值。

Objective To explore the clinical value of serum C-reactive protein in monitoring acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods 72 patients with AECOPD admitted to our hospital from July 2014 to April 2018 were selected as the experimental group,and 72 healthy persons who came to our hospital for physical examination during the same period were selected as the control group.The serum levels of CRP,erythrocyte sedimentation rate(ESR),neutrophil count(NC)and white blood cell count(WBC)were analyzed and compared between the two groups before and after treatment.Results The serum levels of CRP,ESR,NC and WBC in the experimental group were significantly higher than those in the control group,with significant difference between the two groups(P<0.05);the serum levels of CRP in AECOPD patients increased with the aggravation of the disease,and the serum levels of CRP in mild group,moderate group,severe group and extremely severe group were significantly different(P<0.05).Conclusion Serum CRP level in AECOPD patients can accurately reflect the severity of pulmonary infection.Serum CRP level can be used to monitor the changes during treatment,which can adequately reflect the therapeutic effect of AECOPD patients,and has a very high guiding value for the treatment of patients.