血清胱抑素C与多发性肌炎心血管危险因素的临床分析

Clinical evaluation of correlation of serum cystatin C level to the risk factors for cardiovascular disease in patients with polymyositis

目的探讨多发性肌炎患者血清胱抑素C与传统心血管危险因素的关系。方法选择2006年1月-2017年9月成都市第三人民医院住院部收治的多发性肌炎患者88例,根据血清胱抑素C水平分为血清胱抑素C升高组(53例)和非血清胱抑素C升高组(35例)。比较2组患者临床特征,采用Spearman相关分析评估血清胱抑素C与传统心血管疾病相关危险因素如年龄、收缩压、甘油三酯的关系,最后采用多因素logistic回归分析评估与血清胱抑素C相关的心血管疾病危险因素。结果60.2%(53/88)的多发性肌炎患者血清胱抑素C升高。与血清胱抑素C正常组比较,血清胱抑素C升高组的年龄(P=0.008)及甘油三酯(P=0.004)差异有统计学意义。Spearman相关性分析显示,多发性肌炎患者血清胱抑素C水平与年龄、甘油三酯呈正相关(r分别为0.296、0.282,均P<0.05)。多因素logistic回归分析结果显示:甘油三酯水平(OR=2.415,95%CI:1.189~4.905)与血清胱抑素C水平密切相关(P<0.05)。结论多发性肌炎患者血清胱抑素C水平与甘油三酯有关。

Objective To explore the relationship between serum levels of cystatin C and traditional cardiovascular risk factors in patients with Polymyositis(PM).Methods A total of 88 cases patients with PM in the Third People’s Hospital of Chengdu from January 2006 to September 2017 were selected and divided into group A(with elevated serum cystatin C,n=53)and B group(normal serum cystatin C,n=35)according to serum cystatin C level.The clinical features were compared between the two groups,and Pearson correlation analysis was carried out to analyze the correlation between serum cystatin C and cardiovascular risk factors such as age,systolic pressure(SBP),triglyceride(TG).Multivariate logistic regression analysis was used to analyze the related cardiovascular risk factors of serum cystatin C.Results The prevalence of elevated serum cystatin C was 60.2%(53/88).There were significant statistical differences in age(P=0.008)and triglyceride(P=0.004)between the two groups.Spearman correlation analysis showed that serum cystatin C levels was positively correlated with age(r=0.296,P<0.05)and TG(r=0.282,P<0.05).Multivariate logistic regression analysis showed that TG(OR=2.415,95%CI:1.189-4.905)was closely associated with serum cystatin C level in patients with PM(P<0.05).Conclusion Changes of serum cystatin C concentration may be associated with TG.