针刺联合中药治疗腹泻型肠易激综合征患者的效果观察

Analysis of the Acupuncture combined with Traditional Chinese Medicine in the treatment of diarrhea-predominant pattern irritable bowel syndrome patients

目的探究针刺联合中药治疗在腹泻型肠易激综合征(IBS-D)患者中的应用效果。方法选取2015年3月-2017年4月浙江省立同德医院收治的80例IBS-D患者,按随机数字表法将其分为观察组(40例)和对照组(40例)。对照组采用中药治疗,观察组在对照组的基础上加用针刺治疗。比较2组患者的临床疗效、情绪相关指标及神经活性物质水平。结果观察组患者总有效率为92.5%,对照组患者总有效率为72.5%,观察组总有效率明显高于对照组(P<0.05);治疗前2组患者抑郁自评量表(SDS)及焦虑自评量表(SAS)评分比较差异无统计学意义(均P>0.05),治疗后2组患者SDS及SAS评分明显低于治疗前(均P<0.05),且观察组SDS及SAS评分明显低于对照组(均P<0.05);治疗前2组患者神经肽Y(NPY)、5-羟色胺(5-HT)及降钙素基因相关肽(CGRP)水平比较差异无统计学意义(均P>0.05),治疗后2组患者NPY、5-HT、CGRP水平明显低于治疗前(均P<0.05),且观察组NPY、5-HT、CGRP水平明显低于对照组(均P<0.05)。结论针刺联合中药治疗IBS-D疗效显著,可有效改善患者的情绪及神经功能。

Objective To explore the effect of acupuncture combined with Traditional Chinese Medicine therapy on diarrehea-predominant pattern irritable bowel syndrome(IBS-D)patients.Methods A total of 80 patients with IBS-D who were treated in our hospital from March 2015 to April 2017 were selected,and they were randomly divided into observation group(n=40)and control group(n=40)according to the random number table method.The control group was treated with Traditional Chinese Medicine,and the observation group was treated with acupuncture therapy based on the control group.The clinical effect,emotional related indicators and neuroactive substances level were compared between the two groups.Results The total effective rate of patients in observation group was 92.5%,and the total effective rate of patients in control group 72.5%,the total effective rate in observation group was significantly higher than that of control group(P<0.05).Before treatment,there were no significant differences in the scores of elf-rating depression scale(SDS)and self-rating anxiety scale(SAS)between the two groups(all P>0.05);after treatment,the scores of SDS and SAS in the two groups were significantly lower than those before treatment(all P<0.05),and the scores of SDS and SAS in observation group was significantly lower than those of control group(all P<0.05).Before treatment,there were no significant differences in the levels of neuropeptide Y(NPY),5-hydroxytryptamine(5-HT)and calcitonin gene-related peptide(CGRP)between the two groups(all P>0.05);after treatment,the levels of NPY,5-HT and CGRP in the two groups were significantly lower than those before treatment(all P<0.05),and the levels of NPY,5-HT and CGRP in observation group was significantly lower than those of control group(all P<0.05).Conclusion The acupuncture combined with Traditional Chinese Medicine therapy has remarkable effect in treatment of IBS-D,which can obviously improve the emotional and nerve function of patients.