清热消痤汤联合熏蒸治疗肺经风热型中轻度寻常痤疮的临床观察

Clinical observe of Qingre Xiaocuo Decoction combined with fumigation in the treatment of moderate and mild acne vulgaris of lung meridian and wind-heat type

目的观察清热消痤汤联合熏蒸治疗肺经风热型中轻度寻常痤疮的临床疗效。方法以2017年8月-2018年8月于嘉兴市中医医院治疗的124例肺经风热型中轻度寻常痤疮患者为研究对象,按随机数字表法分为对照组(n=62)和研究组(n=62)。对照组给予维A酸联合盐酸米诺环素治疗,研究组予以清热消痤汤联合熏蒸治疗。检测2组血清TNF-α、IL-6和IL-8水平变化,统计治疗后痤疮皮损消减的起效时间,观察药物不良反应,评价疗效水平,随访治疗后6个月内复发情况。结果研究组治疗后血清TNF-α、IL-6和IL-8水平均低于对照组(P<0.05);研究组治疗起效时间(10.72±2.47)d短于对照组(15.31±4.10)d(P<0.05);研究组总体有效率(93.55%)与对照组(88.71%)比较差异无统计学意义(P>0.05);研究组痤疮复发率(10.34%)低于对照组(25.45%,P<0.05);治疗期间,研究组药物不良反应发生率(4.84%)低于对照组(16.13%,P<0.05)。结论中西医治疗肺经风热型中轻度寻常痤疮均可有效改善临床症状,然清热消痤汤联合熏蒸可显著降低患者炎症反应强度,缩短病情控制周期,预防痤疮病情复发,不良反应更少。

Objective To observe the clinical effect of Qingre Xiaocuo Decoction combined with fumigation in the treatment of moderate and mild acne vulgaris of lung meridian and wind-heat type.Methods A total of 124 patients with moderate and mild acne vulgaris of lung meridian wind-heat type in the Jiaxing Hospital of Traditional Chinese Medicine from August 2017 to August 2018 were divided into control group(n=62)and research group(n=62)according to random digital form.The control group was treated with retinoic acid combined with minocycline hydrochloride,while the research group was treated with Qingre Xiaocuo Decoction combined with fumigation.The TNF-α,IL-6 and IL-8 levels in serum were measured,the onset time of acne lesion reduction after treatment was counted,the adverse drug reactions were observed during treatment,the curative effect was evaluated,and the recurrence was followed up within 6 months.Results The levels of serum TNF-α,IL-6 and IL-8 in the research group were lower than those in the control group after treatment(P<0.05).The onset time of acne lesion reduction in the research group(10.72±2.47)d were shorter than those in the control group(15.31±4.10)d(P<0.05).There was no significant difference in the overall effective rate between the research group(93.55%)and the control group(88.71%)(P>0.05).The recurrence rate of acne vulgaris in the research group(10.34%)was lower than that in the control group(25.45%,P<0.05).The overall incidence of adverse drug reactions in the research group(4.84%)was lower than that in the control group(16.13%,P<0.05).Conclusion Both traditional Chinese and Western medicine can effectively improve clinical symptoms of moderate and mild acne vulgaris of lung meridian wind-heat type.However,Qingre Xiaocuo Decoction combined with fumigation can significantly reduce the intensity of inflammatory reaction,shorten the disease control cycle,prevent the recurrence of acne,and have fewer adverse reactions.