基于肠道益生菌的中药防治疾病作用研究进展

Research Advance in Therapeutic Effect of Traditional Chinese Medicine Based on Gut Probiotics

肠道菌群失调是骨质疏松症、肥胖症、糖尿病等多种代谢疾病发生的重要原因之一。肠道益生菌有利于维持肠道微生态平衡、预防疾病发生。此外,许多中药还具有促进肠道益生菌生长的效用,在肠道菌群紊乱调节等方面具有显著作用。同时,肠道益生菌含有多种酶类,能促进中药成分的转化,提高生物利用率。现将近年来基于肠道中益生菌的中药强体防病研究进行综述,为未来中医药的肠道菌群作用靶点及机制研究奠定基础,也为中药学及中医药微生态学的进一步研究提供指导。

The imbalance of intestinal flora is a large contributor to multiple metabolic diseases,such as osteoporosis,obesity,diabetes.Probiotics are crucial component of gut contribute to maintaining intestinal microecological balance and preventing diseases.Many traditional Chinese medicines play an important role in promoting probiotics growth and regulating intestinal flora disturbance.Besides,probiotics are rich in enzymes,which could promote the metabolism of traditional Chinese medicine effective ingredients and improve the bioavailability.This review summarized the recent studies on therapeutic effects of traditional Chinese medicine based on gut probiotics,aiming to provide theoretical guidance and practice for target and mechanism study of traditional Chinese medicine on gut,and further study of traditional Chinese medicine microecology.