中药调控肠道菌群防治心脏疾病的研究进展

Research Progress of Traditional Chinese Medicine in Regulating Gut Microbiota in the Prevention and Treatment of Heart Disease

肠道菌群是当今研究的热点,菌群的失衡与疾病的发生息息相关。肠道菌群在代谢性疾病,如2型糖尿病、肥胖和动脉粥样硬化中研究较多,也有与血管功能性障碍为主的血管类疾病和心脏疾病关系的研究报道。本综述探讨了肠道菌群对心脏疾病发生发展的影响及中药与肠道微生物相互作用防治心脏疾病的作用机理,并由此展望了中药通过调节肠道微生物防治心脏疾病的研究方向。

The research on the gut microbiota has been a new hotspot in the field of life science.Gut microbiota disturbance is closely related to the occurrence and development of diseases.Although most of the studies focus on gut microbiota in metabolic diseases,such as type 2 diabetes and obesity.The relationship between gut microbiota and vascular diseases as well as heart diseases has attracted much attention recently.In this review,we summarized the role of gut microbiota in the pathogenesis of heart diseases,the interaction between traditional Chinese medicine and intestinal microorganisms,the common cardioprotective traditional Chinese medicine by rebalancing gut microbiota.The further research direction of traditional Chinese medicine for the prevention and treatment of cardiac diseases via regulating gut microbiota balance is prospected.