3905例体检人群维生素D水平现状及影响因素研究

Situation of vitamin D level and its influencing factors in 3905 subjects receiving physical examination

目的了解近两年北京市朝阳区体检人群维生素D水平的现状,探讨影响维生素D缺乏的因素及与血脂的相关性。方法采用横断面研究纳入于北京市第一中西医结合医院体检的受试者3905例,抽取静脉血检测其25-羟基维生素D[25(OH)D]和血生化指标,采用多元线性回归分析评估25(OH)D与血脂的相关性。结果所有受试者的血清25(OH)D平均水平为(16.22±6.95)ng/ml,其中25(OH)D严重缺乏636例(16.29%),缺乏2372例(60.74%),不足713例(18.26%),充足184例(4.71%)。不同25(OH)D水平受试者的性别、年龄、体重、BMI、腰围、腰臀比、收缩压、舒张压、空腹血糖(FPG)、尿酸(UA)、肌酐(Cr)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)比较差异均有统计学意义(P<0.05)。不同性别(P=0.010)、不同BMI和性别(P=0.030)、不同季节体检(P<0.001)的受试者25(OH)D水平比较差异均有统计学意义。不同25(OH)D水平受试者的年龄分布比较差异有统计学意义(P<0.001)。多元线性回归分析结果显示25(OH)D水平分别与TC(r=-0.35,P=0.016)、TG(r=-0.28,P=0.046)、LDL-C(r=-0.33,P=0.022)、腰围(r=-0.30,P=0.035)和腰臀比(r=-0.30,P=0.032)呈负相关,与HDL-C(r=0.27,P=0.049)呈正相关。结论北京市朝阳区维生素D水平缺乏状况较为普遍,需引起重视;维生素D水平缺乏与年龄、性别、季节变化、腰围、腰臀比、BMI及血脂相关。

Objective To investigate the situation of vitamin D level in Chaoyang district of Beijing in recent two years,and explore the influencing factors of vitamin D deficiency and the correlation with blood lipid.Methods A cross-sectional study was conducted to include 3 905 subjects who underwent physical examination at Beijing first integrated traditional Chinese and western medicine hospital.Venous blood was taken to test 25-hydroxy-vitamin D[25(OH)D]and blood biochemical indexes.Multiple linear regression analysis was used to evaluate the correlation between 25(OH)D and blood lipid.Results The average serum 25(OH)D level of all subjects was(16.22±6.95)ng/ml,deficiency serious was found in 636 cases(16.29%),deficiency was found in 2 372 cases(60.74%),insufficiency was found in 713 cases(18.26%),plenty was found in 184 cases(4.71%).Subjects with different 25(OH)D levelshad statistically significant differences in gender,age,weight,BMI,waist circumference,waist-to-hip ratio,systolic blood pressure,diastolic blood pressure,fasting plasma glucose(FPG),uric acid(UA),creatinine(Cr),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)(P<0.05).There were statistically significant differences in 25(OH)D levels among subjects of different gender(P=0.010),different BMI and gender(P=0.030)and physical examination in different season(P<0.001).Age distribution of subjects with different 25(OH)D levels was statistically significant(P<0.001).The results of multiple linear regression analysis showed that 25(OH)D level was negatively correlated with TC(r=-0.35,P=0.016),TG(r=-0.28,P=0.046),LDL-C(r=-0.33,P=0.022),waist circumference(r=-0.30,P=0.035),waist-to-hip ratio(r=-0.30,P=0.032),and positively correlated with HDL-C(r=0.27,P=0.049).Conclusion Vitamin D deficiency in Chaoyang district of Beijing is common and should be paid attention.Vitamin D deficiency is associated with age,gender,seasonal variation,waist circumference,waist-to?hip ratio,BMI and blood lipid.