基因芯片在防治动脉粥样硬化中的应用进展

Progress of gene chip in the prevention and treatment of atherosclerosis

基因芯片技术是伴随人类基因组计划应运而生的一项基因检测技术,它与传统的基因检测技术如PCR最大不同在于可平行完成多项遗传实验,大大加快了基因检测的速度。动脉粥样硬化作为缺血性心血管疾病的主要病理基础,其发病机制尚未完全阐明。利用基因芯片技术,可快速对海量基因进行检测,这为研究动脉粥样硬化的发生、发展机制提供了极大的便利。文章主要从基因筛查、微小RNA的检测、分析药物或疗法的作用机制、临床应用及意义等四方面,就目前基因芯片技术在防治动脉粥样硬化上的应用进行综述。

Gene chip technology is a gene detection technology which came into being with the human genome project.The biggest difference between it and traditional gene detection technology such as PCR is that it can complete multiple genetic experiments in parallel,greatly accelerating the speed of gene detection.As the main pathological basis of ischemic cardiovascular disease,the pathogenesis of atherosclerosis has not been fully elucidated.Using gene chip technology,a large number of genes can be detected quickly,which provides great convenience for the study of the pathogenesis and development mechanism of atherosclerosis.This article reviews the application of gene chip technology in the prevention and treatment of atherosclerosis from four aspects:gene screening,microRNA detection,analysis of drug or therapy mechanism,clinical application and significance.