肌少症对重症老年病人的影响及营养治疗

The effect of sarcopeniaand frailty in critically ill elderly patients and nutritional therapy

自从肌少症作为一种疾病纳入ICD-10疾病编码以来,肌少症的关注度逐步提高,对于肌少症的诊断流程,营养治疗方法的研究也逐渐增多。ICU肌少症病人的死亡率更高,且病人使用呼吸机时间及住院时间都延长,故肌少症对ICU住院病人的临床结局有预测作用。肌少症在ICU老年住院病人中普遍存在,而提供医学营养治疗能缩短病人的住院时间、降低病人的死亡率。对肌少症的治疗目前主要有运动、康复、药物、营养等方法。在营养治疗领域,氨基酸有促进肌肉蛋白质合成的直接作用,因此应用亮氨酸及其代谢物治疗ICU肌少症值得探讨。

Since sarcopenia has been awarded an ICD-10 code as a disease,there has been an increasing focus on sarcopenia,as well as an increasing number of studies on the diagnosis process of sarcopenia and nutrition therapy.Relatively,ICU patients with sarcopenia have a higher mortality,use the ventilator for a longer time and prolong hospitalization.Therefore,sarcopenia can predict the clinical outcome of ICU inpatients.Sarcopeniais prevalent in ICU elderlyin patients,andproviding medical nutrition therapy can shorten thehospital staysof patients and decrease their mortality.At present,the treatment methods of sarcopenia mainly include exercise,rehabilitation,medicine,nutrition,et al.In the field of nutritional therapy,amino acids play a direct role in promoting muscle protein synthesis.Therefore,the application of leucine and its metabolites in the treatment of sarcopenia in ICU inpatients is worth discussing.