慢性肾脏病肌少症的发病机制研究进展

Research progress on the pathogenesis of Sarcopenia in chronic kidney disease

肌少症是一种进行性的以骨骼肌质量下降、力量减弱、功能降低为主要特点的临床综合征。老年人群中该病发病率高,随着肾功能减退,肌少症发病率进一步升高。肌少症不仅增加慢性肾脏病病人的经济负担,还严重影响病人生活质量和增加死亡率。本文主要就慢性肾脏病肌少症的发病机制做一综述,以期提高医务工作者对慢性肾脏病肌少症的认识。

Sarcopenia is a progressive syndrome mainly characterized by a decrease in skeletal muscle mass,strength and function.The incidence rate is high in the elderly population,and the incidence is further increased with renal dysfunction.Sarcopenia not only increases the financial burden of patients with chronic kidney disease,but also seriously affects the patients'quality of life and increases mortality.In order to improve medical workers'understanding of sarcopenia in chronic kidney disease,this article mainly reviews the pathogenesis of the disease.