二甲双胍降糖外作用的最新研究进展

The latest research progress of metformin on the effect beyond hypoglycemic

二甲双胍是2型糖尿病患者的首选一线降糖药,近年来大量国内外研究表明,二甲双胍不仅在控制糖尿病患者血糖水平达标及干预治疗糖耐量受损人群等降糖方面有显著效果,而且在降糖外领域表现出"神奇"作用,除了早期发现的可用于治疗代谢综合征、多囊卵巢综合征,控制体质量、血压、血脂,降低心血管事件发生风险外;二甲双胍还能发挥抗肿瘤、抗炎作用及能够延缓衰老、治疗抑郁等精神疾患。

Objective Metformin(MET)is the first-line medications of choice for patients with type 2 diabetes.In recent years,a large number of studies at home and abroad have shown that metformin not only has significant effects in controlling blood sugar level of diabetic patients and intervening in impaired glucose tolerance,but also has"magical"effects in in the field of hypoglycemic outside.In addition to the early discovery that metformin can be used to treat metabolic syndrome and polycystic ovary syndrome,control body weight,blood pressure,blood lipid,and reduce the risk of cardiovascular events,metformin can also play anti-tumor,anti-inflammatory effects,delay aging,and treat mental disorders such as depression.This article reviews the effect of metformin in the field out of hypoglycemic.