低温常压等离子技术在肿瘤学中的应用

Application of Low-Temperature Atmospheric-Pressure Plasma in Oncology

等离子医学是研究等离子技术在医学领域应用的一门新兴科学。简述低温常压等离子技术,着重介绍其在肿瘤学中的应用。在肿瘤学领域中,等离子技术通过直接处理肿瘤细胞,产生大量活性物质引起肿瘤细胞的凋亡、坏死和自噬,从而发挥对肿瘤组织的直接致死性作用;等离子技术也可通过活化液体,使活化液体具备细胞毒性作用,从而发挥对肿瘤组织的间接致死性作用;同时等离子技术也具有诸多对肿瘤组织的非致死性作用;此外等离子技术也可参与构建化疗药物的缓释系统,协助药物跨生物膜转运,与传统化疗药物产生协同抗肿瘤的作用等,在肿瘤药物学领域发挥重要作用。

Plasma medicine is an emerging field focusing on the application of plasma in medicine.In this review,we provided a brief overview of the low-temperature atmospheric-pressure plasma(LT-APP)first,and then focused on the application of LT-APP in oncology.In oncological application,direct plasma treatment to tumor cells can induce the apoptosis,necrosis and autophagy by generating large amounts of reactive agents;Plasma can also kill the cancer cells indirectly via the cytotoxicity of plasma activated liquids.On the other hand,plasma also has several non-fatal effects on tumors as well.In addition,plasma plays an important role in the field of anti-cancer drugs by participating in the construction of sustained-release systems of chemotherapeutic drugs,assisting drug transportation,and having a synergistic anti-tumor effect with traditional chemotherapeutic drugs.