干扰素联合热毒宁治疗手足口病的疗效观察

Observation of curative effect of interferon combined with Reduning in treatment of hand-foot-mouth disease

目的探讨热毒宁联合干扰素治疗手足口病的疗效。方法选取2015年8月至2018年12月本院收治80例手足口病患儿作为研究对象,采用随机数字表法分为观察组(给予利巴韦林)、干扰素组、热毒宁组、干扰素+热毒宁组,各20例。其中观察组(给予利巴韦林)男患儿12例,女患儿8,年龄(1~5)岁,平均年龄(3.43±1.21)岁;干扰素组男患儿11例,女患儿9,年龄(1~5)岁,平均年龄(3.38±1.08)岁;热毒宁组男患儿13例,女患儿7,年龄(1~5)岁,平均年龄(3.97±1.35)岁;干扰素+热毒宁组男患儿12例,女患儿8,年龄(1~5)岁,平均年龄(3.42±1.26)岁。四组患儿临床一般资料比较,无显著差异(P>0.05),分组高度均衡,具有可比性。结果①热毒宁联合干扰素组患儿热退、皮疹/疱疹消退及口腔溃疡愈合时间早于观察组,且热毒宁及干扰素组平均住院时间短于其它三组,其差异比较均有统计学意义(P<0.05)。而其它三组数据并相比较并没有明显差异(P>0.05)。②热毒宁联合干扰素组总有效率高达95.00%高于其它三组总有效率(观察组75.00%、热毒宁组85.00%、干扰素组75.00%),经χ^2检验,观察组总有效率与干扰素组总有效率无明显差异(P>0.05),其它两组均具有显著性差异(P<0.05),统计有意义。(χ^2值=23.491,P=0.0131)。③四组患儿经过不同方法治疗后,热毒宁及干扰素组没有出现一例不良反应,而其它三组均不同程度的出现不良反应,均具有显著性差异(P<0.05),统计有意义。(χ^2值=4.324,P=0.0027)。结论干扰素联合热毒宁治疗手足口病患儿疗效显著,且未出现不良反应,值得临床推广运用。

Objective To investigate the therapeutic effect of Reduning combined with interferon in the treatment of hand-foot-mouth disease.Methods From August 2015 to December 2018,80 children with HFMD who were admitted to our hospital were chosen as the research subjects.The random number method was used to divide all cases into the observation group(giving Ribavirin),Interferon group,Reduning group and Interferon plus Reduning group,with 20 cases in each group.Among them,12 boys and 8 girls in the observation group(given to ribavirin)were aged from 1 to 5 years and the average age was 3.43±1.21 years old;11 boys and 9 girls were in the interferon group who aged from 1 to 5 years,with an average age of 3.38±1.08 years old;There were 13 boys and 7 girls in the Reduning group,who aged between 1 and 5 years old,and the average age was 3.97±1.35 years old;There were 12 cases of male children and 8 female children in the interferon plus Reduning group,whose age were from 1 to 5 years old,with an average age of 3.42±1.26 years old.Clinical fundamental data of four groups had no significant difference(P>0.05),which showed each group was highly balanced and comparable.Results①The fever time,rash/herpes subsidence and oral ulcer healing time in interferon plus Reduning group was earlier than those in the observation group,and the average hospital stay in interferon group plus Reduning was shorter than that in the other three groups,the difference was statistically significant(P<0.05).There were no significant differences between the other three groups(P>0.05).②The total effective rate of interferon combined with Reduning group was 95.00%,which was higher than that in other three groups(75.00%in observation group,85.00%in Reduning group and 75.00%in interferon group).By χ^2 test,there was no significant difference between the total effective rate of observation group and interferon group(P>0.05),and there was significant difference between the other two groups(P<0.05,χ^2 value=23.491,P=0.0131).③After treatment with different methods,there was no adverse reaction in interferon combined with Reduning group, but the other three groups had adverse reactions in different degrees, andthere was significant difference(P < 0.05, χ^2 value = 4.324, P = 0.0027). Conclusion Interferon combined with Reduning is effective inthe treatment of children with HFMD.