老年2型糖尿病患者血糖控制状况与合并骨质疏松症的相关性研究

Correlation between the glucose control status and osteoporosis in elderly patients with type 2 diabetes mellitus

目的探讨老年T2DM患者的血糖控制状况与合并骨质疏松症(OP)的相关性。方法选取2016年5月至2017年5月于我院内分泌科就诊的340例老年T2DM合并OP患者,分为HbA1c<7.0%组(n=172)及HbA1c≥7.0%组(n=168),测定两组血清生化指标及骨密度(BMD)。结果HbA1c<7.0%组年龄、WC、BMI、糖尿病病程、FPG、2 hBG和L-DLC低于HbA1c≥7.0%组(P<0.05),适度运动、多药口服、2~4腰椎及股骨颈BMD高于HbAlc≥7.0%组(P<0.05)。老年T2DM合并OP与ISI呈正相关,与年龄、糖尿病病程、BMI、HbA1c呈负相关。结论血糖控制差的老年T2DM患者BMD降低;合并OP受年龄、糖尿病病程、BMI、HbA1c的影响。

Objective To investigate the control status of blood glucose in elderly patients with type 2 diabetes mellitus(T2DM)and its relationship with osteoporosis.Methods We retrospectively analyzed the clinical data of 340 T2DM patients complicated with osteoporosis treated in our hospital from May 2016 to May 2017.According to the levels of HbA1 c,the patients was divided into HbA1 c,<7.0%group(n=172)and HbA1 c≥7.0%group(n=168).The serological parameters and bone mineral density(BMD)were measured.Results Compared with HbAlc≥7.0%group,the age,WC,BMI,duration of disease,FPG,2 hBG and LDL-C were lower in group with HbA1 c<7.0%(P<0.05).The proportion of patients taking moderate exercise and multiple oral drugs in HbA1 c<7.0%group was higher(P<0.05).The BMD in levels of lumbar 2~4 and femoral neck in HbA1 c<7.0%group were higher than that in HbA1 c≥7.0%group(P<0.05).Osteoporosis in elderlyT2DM patients was positively correlated with the insulin sensitivity index and negatively correlated with age,duration,BMI and HbA1 c.Conclusion BMD is reduced in elderly T2DM patients with poor glycemic control.