骨组织工程用镁基泡沫生物材料的制备与其体外降解行为（英文）

Preparation and in Vitro Degradation Behavior of Mg-based Foam Biomaterials for Bone Tissue Engineering

采用熔体发泡法制备了一种镁基泡沫生物材料,其中以镁钙合金为基体材料,羟基磷灰石(HA)为增粘剂,碳酸镁(Mg CO3)为发泡剂。对结构均匀的镁基泡沫生物材料进行测试,研究其生物可降解行为。用腐蚀前后的孔结构、浸泡试验和电化学测试对镁基泡沫材料的生物可降解性进行表征。结果表明,在固定时间内随着试样孔隙率的增加,失重率不断增加;相比于添加了HA的样品,不含HA颗粒的样品呈现出更高的质量损失率。同时,Mg基泡沫生物材料的总孔隙率和HA含量均对Mg基泡沫材料的开孔率有重要的影响。在相同时间内,开孔率随试样总孔隙率的增加而增加。在模拟体液(SBF)介质中,含有HA的Mg基泡沫生物材料比不添加HA的试样具有更高的耐腐蚀性。

Mg-based foam biomaterials were prepared by a melt foaming process,with Mg-Ca alloy as the matrix material,hydroxyapatite(HA)as the tackifier,and Mg CO3 as the foaming agent.The Mg-based foam biomaterials with uniform structure were tested to investigate their biodegradable behaviors.The biodegradable property of the Mg-based foam was mainly characterized by microstructure observations,immersion tests and electrochemical measurements.The results show that the weight loss rate increases with increasing the porosity of the specimen within a fixed period of time.The weight loss rate of the specimen without HA particles is much higher than that of the specimen with HA particles.Meanwhile,the open porosity of the Mg-based foam biomaterial increases with immersion time.Both the total porosity and added HA content have an important effect on the open porosity of the Mg-based foam biomaterial.Within a fixed period of time,the open porosity of the Mg-based foam biomaterial increases with the increase of the total porosity.Mg-based foam biomaterials added with HA exhibit higher corrosion resistance than Mg-based foam biomaterials without HA in simulated body fluid(SBF)media.