细胞自噬对缺血性脑卒中转归中的作用研究进展

Advances of Autophagy in the Outcome of Ischemic Stroke

自噬是细胞利用溶酶体降解自身受损的细胞器和大分子物质,维持内环境稳态的过程。缺血性脑卒中是一类由于大脑区域的血流供应中断而发生的疾病,由于其发病率较高,寻找治疗窗宽、疗效好的缺血性脑卒中治疗药物成为研究热点。缺血性脑卒中发生后,自噬在大脑许多细胞中被激活,但自噬在脑卒中发病中的作用和机制尚不明确。综述细胞自噬对缺血性脑卒中转归中的作用研究进展,旨在为开发以自噬为靶点的缺血性脑卒中治疗药物提供依据。

Autophagy is a process by which cells use lysosomes to degrade their own damaged organelles and macromolecular substances to maintain homeostasis. Ischemic stroke is a kind of disease that occurs due to the interruption of blood supply in the brain region. Due to the high rate of morbidity, it is necessary to find effective drugs with wide therapeutic window and good efficacy on ischemic stroke. After ischemic stroke, autophagy is activated in many cells of the brain, yet the role and mechanism of autophagy in the pathogenesis of stroke are not well understood. This paper reviews the research progress of autophagy on the outcome of ischemic stroke, so as to provide the basis for the development of autophagy-targeting therapeutic drugs for ischemic stroke.