非编码RNA与妊娠期糖尿病关系的研究进展

Progress in the Study of Non-Coding RNA and Gestational Diabetes Mellitus

妊娠期糖尿病(gestational diabetes mellitus, GDM)是一种常见的妊娠并发症,指在妊娠期间首次发生或诊断的自发性糖耐量异常。近年来研究发现,大量非编码RNA(non-coding RNA,ncRNA)与GDM发生、发展相关,其中包括微小RNA(microRNA, miRNA)、长链非编码RNA(long non-coding RNA, lncRNA)和环状RNA(circular RNA, circRNA)等。该综述将重点讨论miRNA、lncRNA、circRNA及其在GDM的发生、发展中的生物学作用,帮助我们更好地了解ncRNA在GDM中发挥其功能和相互作用的分子机制,为今后的研究提供信息。

Gestational diabetes mellitus(GDM) is a common pregnancy complication that refers to spontaneous glucose intolerance first occurs or diagnosed during pregnancy. In recent years, studies have found that a large number of non-coding RNAs(ncRNA) are involved in the development of GDM, including microRNA(miRNA), long non-coding RNA(lncRNA) and circular RNA(circRNA). This review focuses on the biological roles of miRNA, lncRNA and circRNA in the development and progression of GDM, which helps us better understand the molecular mechanisms by which ncRNAs function and interact with each other in GDM, providing further information for future research.