程序性死亡在急性胰腺炎中的研究进展

Progress in the study of programmed cell death in acute pancreatitis

目的了解现阶段程序性细胞死亡在急性胰腺炎发病机制中的研究进展,以希望为急性胰腺炎的发病机制及治疗提供参考。方法通过阅读近几年国内外的相关文献,对近年来急性胰腺炎与程序性细胞死亡的研究进展进行综述。结果程序性细胞死亡被定义为由细胞内程序执行的受控细胞死亡,包括凋亡、自噬、程序性坏死和焦亡。胰腺腺泡细胞的死亡模式主要包括细胞凋亡和坏死。虽然急性胰腺炎的发病机制尚未完全明确,但通过对程序性细胞死亡的研究,有助于我们对急性胰腺炎的发病机制和病程转归加深理解,以提供更有效的治疗方法。结论程序性细胞死亡在急性胰腺炎的发病中十分重要,研究程序性细胞死亡在急性胰腺炎中的机制对于急性胰腺炎的治疗、预防等有一定的必要性。

Objective To understand the current progress of programmed cell death in the pathogenesis of acute pancreatitis,and to provide reference for the pathogenesis and treatment of acute pancreatitis.Method The research progress of acute pancreatitis and programmed cell death in recent years was reviewed by reading relevant literatures at home and abroad in recent years.Results Programmed cell death was defined as controlled cell death performed by intracellular procedures,including apoptosis,autophagy,programmed necrosis,and coronation.The pattern of death of pancreatic acinar cells mainly includes apoptosis and programmed necrosis.Although the pathogenesis of acute pancreatitis had not yet been fully clarified,it was known that through the study of programmed cell death,it could help us to understand the pathogenesis and pathogenesis of acute pancreatitis and provide more effective treatment methods.Conclusions Programmed cell death is very important for acute pancreatitis.The mechanism of programmed cell death in acute pancreatitis is necessary for the treatment and prevention of it.