p53基因家族与甲状腺癌的相关研究进展

Advances of relationship between p53 gene family and thyroid cancer

目的探讨p53基因家族在甲状腺癌中的作用。方法在数据库内对p53基因家族在甲状腺癌中研究的相关文献进行综述并分析。结果p53基因家族包括p53、p63及p73。p53在甲状腺癌发生及发展中发挥着重要作用,尤其是在甲状腺未分化癌的进展中;p63不同亚型在甲状腺癌中可能具有不同作用,因此不能笼统地说其是癌基因或抑癌基因,其特定蛋白的功能还需要进一步研究;p73在甲状腺细胞中的生物学作用可能是矛盾的,取决于很多不同因素的交互作用,各种p73亚型和p53分子网络内的成员之间作用尚不清楚。结论p53基因家族在甲状腺癌的发生及发展中的作用还有一些争议,有待进一步研究。

Objective To investigate the relationship between p53 gene family and thyroid cancer.Method The related literatures in the database were reviewed and analyzed.Results The p53 gene family included p53,p63,and p73.The p53 played an important role in the development of thyroid cancer,especially in the development of undifferentiated thyroid cancer.The different subtypes of p63 might have different roles in the thyroid cancer,so it couldn’t be generally said that the p63 was an oncogene or an anti-oncogene,and the function of its specific protein needed to be further studied.The biological role of p73 in the thyroid cells might be contradictory,depending on the interaction of many different factors,and the interaction between various p73 subtypes and members of the p53 molecular network was still unclear.Conclusion There is still some controversy about role of p53 gene family in development of thyroid cancer.