清热解毒烧伤膏联合亲水性银离子敷料治疗深Ⅱ度烧伤临床研究

Clinical efficacy of Qingre-Jiedu-Shaoshang ointment combined with hydrophilic silver ion dressing in patients with deep degree Ⅱ burns

目的 评价清热解毒烧伤膏联合亲水性银离子敷料治疗深Ⅱ度烧伤的疗效.方法 将符合入选标准的89例深Ⅱ度烧伤患者采用随机数字表法分为对照组44例、治疗组45例.对照组给予亲水性银离子敷料治疗,治疗组在对照组基础上加用清热解毒烧伤膏治疗.2组均连续治疗21 d.观察并记录2 组患者的创面愈合时间与换药次数,采用 VAS 量表评价创面的疼痛程度,采用 ELISA 法检测血清TNF-α、IL-6水平,评价临床疗效.结果 治疗组总有效率为95.6%(43/45)、对照组为77.3%(34/44),2组比较差异有统计学意义(χ2=6.375,P=0.012).治疗组创面愈合时间[(17.3±1.9)d 比(22.5±2.2)d,t=11.987]早于对照组(P<0.01),换药次数[(5.1±0.7)次比(7.4±0.8)次,t=15.041]少于对照组(P<0.01);治疗组治疗后7、14、21 d时VAS评分均低于对照组(t值分别为10.597、19.692、26.510,P值均<0.001);治疗组治疗后血清TNF-α、IL-6水平均低于对照组(t值分别为6.412、8.202,P值均<0.01).结论 清热解毒烧伤膏联合亲水性银离子敷料可有效促进深Ⅱ度烧伤患者的创面愈合,减轻创面疼痛程度,降低炎性细胞因子水平,提高临床疗效.

Objective To evaluate the efficacy of Qinre-Jiedu-Shaoshang ointment combined with hydrophilic silver ion dressing in the treatment of deep degree Ⅱ burn. Methods A total of 89 patients with degreeⅡ burn were enrolled, and they were randomly divided into the control group (44 cases) and the treatment group (45 cases). The control group was treated with hydrophilic silver ion dressing. The treatment group was treated with Qinre-Jiedu-Shaoshang ointment combined with hydrophilic silver ion dressing. Both groups were treated continuously for 21 days. The wound healing time and dressing change times of the two groups was observed and recorded. The VAS scale was used to evaluate the degree of wound pain. The serum level of TNF-α and IL-6 were detected by ELISA. Results The total effective rate was 95.56% (43/45) in the treatment group and 77.27% (34/44) in the control group. There was a significant difference between the two groups ( χ2=6.375, P=0.012). The healing time of wounds in the treatment group (17.3 ± 1.9 d vs. 22.5 ± 2.2 d, t=11.987) and dressing change times (5.1 ± 0.7 times vs. 7.4 ± 0.8 times, t=15.041) were significantly less than those in the control group (P<0.01). The VAS score of the treatment group at 7, 14 and 21 days after treatment was significantly lower than those of the control group (t values were 10.597, 19.692, 26.510, all Ps<0.001). After treatment, the level of serum TNF-α and IL-6 in the treatment group were significantly lower than those in the control group (t values were 6.412, 8.202 respectively, all Ps<0.01). Conclusions The Qinre-Jiedu-Shaoshang ointment combined with hydrophilic silver ion dressing can effectively promote wound healing, reduce the degree of wound pain, reduce the level of inflammatory cytokines, and improve clinical efficacy.