喹硫平与阿立哌唑合用对精神分裂症患者空腹血糖、血脂的影响

Effects of quetiapine combined with aripiprazole on blood glucose and blood lipid inpatients with schizophrenia

目的探讨喹硫平与阿立哌唑合用对精神分裂症患者空腹血糖、血脂的影响。方法随机选取2016年8月~2018年8月我院精神分裂症患者60例,随机分为2组:一组喹硫平与阿立哌唑合用组(合用组,30例),一组单用喹硫平组(单用组,30例),统计分析两组患者的空腹血糖、血脂、PANSS评分、临床疗效、不良反应发生情况。结果合用组患者的GLU、TG、LDL水平均显著低于单用组(P<0.05),G分、N分、P分、PANSS总分均显著低于单用组(P<0.05),治疗的总有效率93.3%(28/30)显著高于单用组76.7%(23/30)(P<0.05)。两组患者的不良反应发生率分别为13.3%(4/30)和13.3%(4/30),无明显差异(P>0.05)。结论喹硫平与阿立哌唑合用较单用喹硫平对精神分裂症患者空腹血糖、血脂的影响小。

Objective To investigate the effects of quetiapine combined with aripiprazole and quetiapine alone on fasting blood glucose and blood lipids of patients with schizophrenia. Method Sixty cases of patients with schizophrenia in our hospital from August 2016 to August 2018 were selected and randomly divided into two groups :one group were treated by quetiapine and aripiprazole(combined group,30 cases),another group were quetiapine(single-use group,30 cases),the fasting blood glucose,blood lipids,PANSS scores,clinical efficacy and adverse reactions of the two groups were statistically analyzed. Results The GLU,TG,and LDL levels of the combination group were significantly lower than those in the single-use group(P<0.05). The G,N,P scores and PANSS total score in the combination group were significantly lower than those in the single-use group(P<0.05). The total effective rate of treatment(93.3%, 28/30)was significantly higher than the single-use group(76.7%.23/30))(P<0.05). There was no difference of incidences of adverse reactions between the two groups [13.3%(4/30),13.3%(4/30)](P>0.05). Conclusion The combination of quetiapine and aripiprazole has less effect on fasting blood glucose and blood lipid in patients with schizophrenia.