佐匹克隆治疗精神分裂症患者睡眠障碍的疗效和安全性

The efficacy and safety of zopiclone in the treatment of sleep disorders on patients schizophrenia

目的探讨佐匹克隆对精神分裂症患者睡眠障碍的疗效和安全性。方法将2016年7月~2019年7月本院收诊的102例精神分裂症患者随机法分为观察组51例(佐匹克隆)与对照组51例(氯硝西泮),比较2组精神分裂症睡眠障碍患者的PSQI评分、治疗有效率、不良反应发生率指标。结果治疗结束,观察组PSQI评分(5.24±0.59)分、不良反应发生率(7.84%)均低于对照组(P<0.05);观察组治疗有效率(98.04%)高于对照组(84.31%)(P<0.05)。结论佐匹克隆可有效改善精神分裂症患者的睡眠障碍,改善其睡眠质量。

Objective To investigate the efficacy and safety of zopiclone in the treatment of sleep disorders in schizophrenia patients. Methods A total of 102 patients with schizophrenia admitted to our hospital from July 2016 to July 2019 were randomly divided into observation group(51 cases)(treatment with zopiclone)and control group(51 cases)(treatment with clonazepam),The PSQI score,treatment efficiency,and incidence of adverse reactions in two groups were compared. Results At the end of treatment,the PSQI score(5.24±0.59)and the incidence of adverse reactions(7.84%)were lower in the observation group than in the control group(P<0.05). The effective rate of treatment in the observation group(98.04%)was high. In the control group(84.31%)and the difference was significant(P<0.05). Conclusion Zopiclone can effectively improve the clinical efficacy of patients with schizophrenia and sleep disorders,reduce its adverse reactions and improve its sleep quality.