多囊卵巢综合征患者发生抑郁的危险因素

The risk factors of depression in patients with polycystic ovary syndrome

目的分析多囊卵巢综合征患者出现抑郁的风险因素。方法选取2018年5月~2019年5月在我院就诊的多囊卵巢综合征伴抑郁患者30例作为合并组,另外在选取同时期未合并抑郁症的患者30例作为未合并组,分析两组患者的一般资料、DBP、SBP、FPG、2hPG、FINS、HOMA-IR、TG、HDL-C、MS发生情况、血清[25(OH)D]水平、BDI评分,多因素Logistic回归分析多囊卵巢综合征患者抑郁症发生的危险因素。结果合并组患者的体质量指数显著高于未合并组(P<0.05),有抑郁症家族史比例显著高于未合并组(P<0.05),SBP、FINS均显著高于未合并组(P<0.05),TG显著高于未合并组(P<0.05),MS发生率56.7%(17/30)显著高于未合并组33.3%(10/30)(P<0.05),血清[25(OH)D]水平显著低于未合并组(P<0.05),BDI评分显著高于未合并组(P<0.05)。血清[25(OH)D]水平与BDI评分呈显著的负相关关系(r=-0.361,P<0.05)。多因素Logistic回归分析显示,多囊卵巢综合征患者抑郁症发生的危险因素包括有抑郁症家族史、MS、血清[25(OH)D]水平<11.5μg/L(P<0.05)。结论多囊卵巢综合征患者血清维生素D水平和抑郁症密切相关。

Objective To analyze the risk factors of depression in patients with polycystic ovary syndrome. Methods 30 cases of polycystic ovary syndrome patients with depression in our hospital from May 2018 to May 2019 were selected as combined group,and the 30 polycystic ovary syndrome patients without depression as non-combined group. The general data,DBP,SBP,FPG,2 hPG,FINS,HOMA-IR and TG,HDL-C,incidences of MS,serum [25(OH)D] levels,BDI scores of the two groups were statistically analyzed. The risk factors of depression of patients with polycystic ovary syndrome were analyzed by multivariate logistic regression. Results Compared with non-combined group,the body mass index(BMI),the proportion of family history of depression,SBP,FINS,TG,the incidence of MS and BDI score in the combined group was significantly higher(P<0.05),the serum [25(OH)D] level was significantly lower(P<0.05). The serum [25(OH)D] level was negatively correlated with BDI score(r=-0.361,P<0.05). Multivariate logistic regression analysis showed that the risk factors of depression of patients with polycystic ovary syndrome included family history of depression,MS and serum [25(OH)D] level < 11.5 ug/L(P<0.05). Conclusion Serum vitamin D level is closely related to depression of patients with polycystic ovary syndrome.