颅脑创伤患者手术后抑郁和血脂的关系

Analysis of the relationship between postoperative fat depression and blood lipids in postoperative patients with traumatic brain injury

目的颅脑创伤患者手术后抑郁和血脂的关系。方法选取2017年8月~2019年1月于我院接受治疗的84例颅脑创伤患者为研究对象,根据是否出现抑郁症(SDS评分≥53分为抑郁症)将患者分为两组,对照组无抑郁症,共46例,观察组合并抑郁症,共38例,比较两组患者的血脂水平(总胆固醇TC、高密度脂蛋白胆固醇HDL-C、低密度脂蛋白胆固醇水平LDL-C以及甘油三酯TG),使用多因素Logisitic分析颅脑创伤患者术后抑郁的危险因素,并使用Pearson法分析血脂水平与抑郁水平的相关性。结果观察组TC,LDL-C和TG水平均高于对照组,HDL-C水平低于对照组(P<0.05);Logisitic回归分析结果显示,高TC水平、低HDL-C水平、高LDL-C水平以及高TG水平是颅脑创伤患者术后抑郁的危险因素;Pearson法分析结果显示,SDS评分与TC、HDL-C、LDL-C以及TG的相关系数r分别为0.402、-0.227、0.389、0.513。结论颅脑创伤患者术后抑郁的发生与血脂水平相关,TC水平、LDL-C以及TG水平升高、HDL-C水平降低提示患者有抑郁症风险。

Objective To explore the relationship between postoperative fat depression in postoperative patients with blood lipids and traumatic brain injury. Method-four postoperative patients with craniocerebral injury who were treated in our hospital from August 2017 to January 2019 were selected as subjects. According to whether there was depression(SDS score ≥ 53),the patients were divided into two groups,the patients without depression were control group(n=46),the patients with depression were observed group(n=38). Blood lipid levels(total cholesterol TC,high-density lipoprotein cholesterol HDL-C,low-density lipoprotein cholesterol level LDL-C,and triglyceride TG)were compared between the two groups. Multivariate Logisitic was used to analyze the risk factors of depression in postoperative patients with traumatic brain injury,and Pearson’s method was used to analyze the correlation between blood lipid levels and depression levels. Result The level of TC,LDL-C,TG in the observation group was higher than those in the control group;the HDL-C level in the observation group was lower than those in the control group(P<0.05). Multivariate Logisitic regression analysis showed that high TC levels,low HDL-C levels,high LDL-C levels,and high TG levels were risk factors for postoperative depression in patients with traumatic brain injury. Pearson analysis showed that the correlation coefficients r of SDS scores with TC,HDL-C,LDL-C and TG were 0.402,-0.227,0.389,and 0.513,respectively. Conclusion There is a certain correlation between the occurrence of depression and blood lipid levels in postoperative patients with traumatic brain injury. The increase of TC level,LDL-C and TG levels,and the decrease of HDL-C level suggest that patients have the risk of depression,which should be paid attention to in clinic.