间歇性禁食在裸鼠体内对肝癌进展的影响

Effect of intermittent fasting on hepatocarcinoma progress in nude mice

为探究间歇性禁食对肝癌进展的影响,以皮下注射肝癌细胞Huh7的BALB/c裸鼠为研究对象,构建肿瘤模型,比较间歇性禁食对肝癌形成及生长、肝脏生理功能及血脂血糖的影响。结果显示:皮下注射Huh7细胞引起的肝癌病变,与对照组相比较,间歇性禁食组小鼠的成瘤率低,且在相同时间段内,间歇性禁食组小鼠形成的肿瘤体积较小;血清学检测结果表明,间歇性禁食组小鼠的肝损伤程度较低。间歇性禁食对肝癌形成具有一定程度的抑制作用,有望成为抑制或减缓肿瘤恶化的有效方法。

To explore the effect of intermittent fasting on the progress of hepatocarcinoma,BALB/c nude mice were injected subcutaneously with Huh7cells to establish the tumor model.Subsequently,the effects of intermittent fasting on hepatocarcinoma formation and growth,physiological function of liver,blood fat and blood glucose were analyzed.The results showed pathological changes of hepatocarcinoma caused by subcutaneous in jection of Huh7.Compared with the control group,tumor formation rate of intermittent fasting mice was low,and in the same time period,tumor size of intermittent fasting mice was small.In addition,the data from serological experiments showed the liver function of intermittent fasting mice had less injury.This study suggested that intermittent fasting could inhibit the formation of hepatocarcinoma,which is expected to be an effective way to inhibit or relieve tumor deterioration.