长期鼓膜穿孔动物模型的研究进展

Advances of chronic tympanic membrane perforation animal model

长期鼓膜穿孔动物模型的用途广泛,理想的模型是具有稳定持久、无感染的穿孔.半个世纪以来,研究者们陆续使用热灼伤、边缘折翻、鼓膜置管、多次鼓膜切开、激光切开鼓膜等物理方法,各种抑制细胞生长修复的化学物质等化学方法,以及使用基因缺陷动物模型来造模的.结果发现单一的某一种造模方法成功率均较低,联合使用化学和物理方法才能获得较高的成功率.本文就制作长期鼓膜穿孔动物模型的研究进展做一文献综述.

Chronic tympanic membrane perforation in an animal model has been widely used.The ideal model is a lasting and stable perforation without infection.For half a century,several physical modalities have been evolved,such as thermal injury,infolding technique,tympanostomy tube,re-myringotomy,and laser myringotomy.Chemical methods using chemical substance inhibiting growth and repair of cells as well as using gene defect animals are also applied.We have found the success rate is lower when using only one method and it would be better to combine physical and chemical approaches.In this article,we review the research advances in the establishment of chronic tympanic membrane perforation animal model.