对2013年～2017年宁德地区孕中期孕妇进行T21、T18血清学筛查的结果分析

Analysis of the results of T21 and T18 serological screening for pregnant women in the second trimester in ningde from 2013 to 2017

目的:分析2013年~2017年宁德地区孕中期孕妇进行21-三体综合征(T21)、18-三体综合征(T18)血清学筛查的结果。方法:选取2013年~2017年期间在宁德市产前诊断机构进行T21、T18血清学筛查的143523例孕中期孕妇作为本次研究的对象。分析对这些孕妇进行T21、T18血清学筛查的结果。结果与结论:在这些孕妇中,进行T21联合T18血清学筛查的结果呈阳性的孕妇占4.09%,进行羊水染色体核型分析的孕妇占1.84%。在进行T21联合T18血清学筛查的结果呈阳性的5868例孕妇中,进行羊水染色体核型分析的孕妇占1.12%。对这些孕妇进行T21血清学筛查的阳性预测值为1.41%,对其进行T18血清学筛查的阳性预测值为35.56%,对其进行T21联合T18血清学筛查的阳性预测值为2.37%。对这些孕妇进行T21联合T18血清学筛查的阳性率为51.35%。2013年~2017年,宁德地区的这些孕中期孕妇进行T21联合T18血清学筛查结果的阳性率分别为1.23%、1.22%、0.95%、1.03%、1.19%;其进行T21、T18及T21联合T18血清学筛查的阳性预测值均有所升高。在进行T21和T18血清学筛查的结果呈阳性的孕妇中,进行羊水染色体核型分析的孕妇所占的比例逐年下降。

objective:to analyze the serological screening results of 21-trisomy 21(T21)and 18-trisomy 18(T18)for pregnant women in the second trimester of pregnancy in ningde region from 2013 to 2017.Methods:143523 pregnant women in the second trimester who underwent T21 and T18 serological screening in the prenatal diagnosis institutions in ningde from 2013 to 2017 were selected as the subjects of this study.The results of serological screening for T21 and T18 were analyzed.Results and conclusion:among these pregnant women,4.09%of the pregnant women who underwent T21 combined with T18 serological screening had positive results,and 1.84%of the pregnant women who underwent amniotic fluid karyotype analysis.Among the 5,868 pregnant women who tested positive for T21 combined with T18 serological screening,1.12% of pregnant women underwent amniotic fluid karyotype analysis.The positive predictive value of T21 serological screening for these pregnant women was 1.41%,the positive predictive value of T18 serological screening for these pregnant women was 35.56%,and the positive predictive value of T21 combined with T18 serological screening for these pregnant women was 2.37%.The positive rate of T21 combined with T18 serological screening in these pregnant women was 51.35%.From 2013 to 2017,positive rates of T21 combined with T18 serological screening were 1.23%,1.22%,0.95%,1.03%and 1.19%,respectively.The positive predictive value of T21,T18 and T21 combined with T18 serological screening increased.Among pregnant women who tested positive for T21 and T18 serological screening,the proportion of pregnant women who performed amniotic fluid karyotype analysis declined year by year.