维生素D水平与小儿呼吸道合胞病毒毛细支气管炎的关系分析

Relationship analysis between vitamin D level and pediatric respiratory syncytial virus bronchiolitis

目的通过检测比较呼吸道合胞病毒毛细支气管炎患儿与健康小儿的维生素D水平,检测比较补充维生素D治疗对患儿血清25(OH)D3水平的影响及治疗效果,探讨维生素D水平与患儿呼吸道合胞病毒毛细支气管炎发病的关系。方法选取2018年1~12月在我院诊治的呼吸道合胞病毒毛细支气管炎患儿80例以及同期在我院进行健康体检的小儿30例作为研究对象。检测比较患儿与健康小儿的维生素D水平。将患儿随机分为维生素D治疗组和常规治疗组,分别给予常规治疗+补充维生素D治疗和常规治疗。检测比较维生素D治疗组和常规治疗组患儿的血清25(OH)D3水平、临床症状体征(喘憋天数、呼吸困难天数、哮鸣音天数)和住院时间。结果呼吸道合胞病毒毛细支气管炎患儿的血清25(OH)D3水平显著高于健康小儿,差异有统计学意义(P<0.05)。治疗前,维生素D治疗组与常规治疗组患儿的血清25(OH)D3水平比较,差异无统计学意义(P>0.05);治疗2个月后,两组患儿的血清25(OH)D3水平均明显升高,维生素D治疗组患儿的水平显著高于常规治疗组,差异有统计学意义(P<0.05)。维生素D治疗组患儿的喘憋天数、呼吸困难天数、哮鸣音天数、住院天数均明显少于常规治疗组,差异有统计学意义(P<0.05)。结论呼吸道合胞病毒毛细支气管炎患儿发病可能与其维生素D缺乏有关,在常规治疗基础上辅以维生素D治疗能有效提高患儿的临床治疗效果,治疗时应密切关注患儿的维生素D营养状况。

Objective To explore the relationship between vitamin D level and the incidence of pediatric respiratory syncytial virus bronchiolitis through detecting and comparing vitamin D level in children with respiratory syncytial virus bronchiolitis with healthy children,and comparing the effect and efficacy of vitamin D supplementation on serum25(OH)D3 level in children with respiratory syncytial virus bronchiolitis.Methods A total of 80 children with respiratory syncytial virus bronchiolitis diagnosed and treated in our hospital from January to December 2018,and 30 children underwent healthy physical examination in our hospital were selected as the objects.The vitamin D level in children with respiratory syncytial virus bronchiolitis and healthy children was detected and compared.The children with respiratory syncytial virus bronchiolitis were randomly divided into vitamin D treatment group and conventional treatment group,with respective conventional treatment plus vitamin D supplement treatment and conventional treatment.Serum 25(OH)D3 level,clinical symptoms and signs(asthma days,dyspnea days,wheezing days),and hospital stays were compared between the vitamin D treatment group and the conventional treatment group.Results Serum 25(OH)D3 level in children with respiratory syncytial virus bronchiolitis was significantly higher than that in healthy children,with statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in serum 25(OH)D3 level between the vitamin D treatment group and the conventional treatment group(P>0.05).After 2 months of treatment,the serum25(OH)D3 level in both groups was significantly increased,and the level in the vitamin D treatment group was significantly higher than that in the conventional treatment group.The difference was statistically significant(P<0.05).Asthma days,dyspnea days,wheezing days and hospital stays in the vitamin D treatment group were significantly shorter than those in the conventional treatment group,with statistically significant difference(P<0.05).Conclusion Vitamin D deficiency may correlate to the incidence of pediatric respiratory syncytial virus bronchiolitis.On the basis of conventional treatment,vitamin D treatment can effectively improve the clinical efficacy.The vitamin D nutritional status in children with respiratory syncytial virus bronchiolitis should be closely concerned throughout treatment.