miRNA与动脉粥样硬化炎症机制研究进展

Potential role of miRNA expression in inflammation during atherogenesis:A review

许多疾病涉及慢性炎症,其中包括动脉粥样硬化。炎症反应是由趋化因子、细胞因子和不同的炎症细胞等共同参与并介导的。目前对动脉粥样硬化炎症调节机制并不完全了解,近年来,许多研究提出miRNA在动脉粥样硬化病程进展和炎症应答过程中有重要作用,它可调节血管内皮细胞、巨噬细胞、组织和免疫应答基因表达稳定性等。多种miRNA,如miR-21、miR-126、miR-145和miR-221等调节了转录后基因沉默并减少炎症介质释放。本综述主要将近期非编码RNA的研究结果,尤其是miRNA在动脉粥样硬化发生和发展的病理机制以及与脂质代谢有关的调节作用做一综述。miRNA可能成为AS的新的诊断性生物学指标,miRNA激动剂或拮抗剂和外源性miRNA可能成为今后治疗动脉粥样硬化新的靶向治疗方法。

Chronic inflammation is involved in many diseases,including atherosclerosis(AS).AS is characterized by the accumulation of lipids and inflammatory cells in the artery wall.Multiple immune cells,inflammatory-related cytokines and chemokines play a key role in its pathophysiology.miRNAs play an important regulatory role in macrophages,vascular endothelial cells,tissues and stability of gene expression in the inflammatory process and pathogenesis of AS,but the underlying mechanisms are largely unknown.In this review,we provide an outline of miRNAs associated with AS and reactivity(miR-145,miR-126,miR-21,miR-221,miR-155,miR-146,miR-19,let-7,miR-10,miR-195).This review mostly focusing in miRNA,mechanism of action and relevance in regulating lipid metabolism and developments in the pathogenesis of atherosclerosis.miRNA should be evaluated as novel biomarkers to improve diagnostics of AS,meanwhile,exogenous miRNA(mimics) agonist and antagonist might be used as a new potential targets strategy for treatment.