骨质疏松发病机制及相关治疗药物研究进展

Progress in the Pathogenesis of Osteoporosis and Related Therapeutic Drugs

骨质疏松症(osteoporosis,OP)是由骨密度降低,骨组织脆性增加、骨强度减低,而使骨折风险增高的全身性骨病。随着OP发生率的逐年提高,特别是老年人及绝经后的妇女发病率高达50%以上,OP已经成为全球性的公共卫生问题。不但增加了个人的痛苦,还给家庭和社会增加了经济负担。该文对OP的发病机制和现阶段常用的治疗方法进行了概括和综述,希望能为研发新型的治疗药物提供些许的帮助。

Osteoporosis(OP) is a systemic bone disease caused by decreased bone density, increased fragility of bone tissue, and reduced bone strength. With the increasing incidence of OP, especially in the elderly and postmenopausal women, the incidence has reached more than 50%, OP has become a global public health problem. Not only has it increased personal suffering, but it has also added an economic burden to families and society. This article summarizes the pathogenesis of OP and the current treatment methods, and hopes to provide some help for the development of new therapeutic drugs.