带状疱疹后遗神经痛患者血清IL-1β水平及其影响因素研究

Serum IL-1β levels and its influencing factors in patients with postherpetic neuralgia

目的:探讨带状疱疹后遗神经痛(PHN)患者血清白细胞介素1β(IL-1β)水平及其影响因素。方法:回顾性纳入2014年1月-2019年1月我院145例PHN患者作为PHN组,另选取40例健康者作为对照组。采用酶联免疫吸附法(ELISA)检测两组研究对象血清IL-1β水平并比较差异,对PHN患者血清IL-1β水平的影响因素采用单因素和Logistic回归分析,采用Pearson相关分析PHN患者血清IL-1β水平与急性期VAS评分的相关性。结果:PHN组患者血清IL-1β水平[(20.18±5.63)pg/mL]与对照组[(10.36±1.19)pg/mL]相比明显升高(t=10.94,P<0.01)。多因素Logistic分析结果显示,PHN患者年龄(OR=3.541)和急性期VAS评分(OR=6.237)与血清IL-1β水平有关(P值均<0.01)。PHN患者血清IL-1β水平与带状疱疹急性期VAS评分具有中度正相关性(r=0.64,P<0.05)。结论:PHN患者血清IL-1β水平明显升高。IL-1β可能参与了PHN的发病,且血清IL-1β水平能反映急性期带状疱疹患者的疼痛程度。

Objective:To investigate the serum IL-1βlevels and its influencing factors in patients with postherpetic neuralgia(PHN).Methods:A total of 145 patients with PHN and 40 healthy controls were enrolled in our hospital from January 2014 to January 2019.Enzyme-linked immunosorbent assay(ELISA)was used to detect serum IL-1βlevels.Single factor and logistic regression analyses were used to determine the influencing factors of serum IL-1βlevels in patients with PHN.Pearson correlation analysis was used to analyze the correlation between serum IL-1βlevels and VAS scores.Results:The serum IL-1βlevels in PHN group were significantly higher than that in the controls[(20.18±5.63)pg/mL vs(10.36±1.19)pg/mL,t=10.94,(P<0.01)].Multivariate logistic analysis showed that age(OR=3.541)and VAS scores of acute stage(OR=6.237)in PHN patients were related to the serum IL-1βlevels.There was a significant positive correlation between serum IL-1βlevels and VAS scores,with the correlation coefficient of r=0.64(P<0.05).Conclusions:The serum IL-1βlevels in patients with PHN increase significantly,and IL-1βmay be involved in the pathogenesis of PHN.IL-1βcan reflect the severity of pain in patients with herpes zoster in acute stage.