复方槐花补骨脂酊联合NB-UVB治疗稳定期散发型白癜风疗效观察

Efficacy of tincture of compound Flos Sophorae and Fructus Psoraleae in combination with NB-UVB for stable sporadic vitiligo

目的:观察复方槐花补骨脂酊联合NB-UVB治疗稳定期散发型白癜风的疗效及安全性。方法:将190例稳定期散发型白癜风患者随机分为治疗组和对照组。对照组患者外搽本院制剂“白消酊”后外涂丙酸氟替卡松乳膏,同时联合窄谱中波紫外线(NB-UVB)治疗;治疗组在“白消酊”中添加槐花、侧柏叶乙醇提取液混合成复方槐花补骨脂酊外搽,其余治疗方法同对照组;疗程半年,治疗3个月及6个月判定疗效。结果:治疗第3个月及6个月,治疗组显效率分别为58.76%、83.51%,对照组显效率分别为41.94%、50.54%,两组显效率差异有统计学意义(X^2值分别为5.38、23.47,P值均<0.05);治疗6个月,治疗组与对照组痊愈率分别为45.36%、22.58%,两组痊愈率比较,差异有统计学意义(X^2=10.95,P<0.01)。两组均未见明显不良反应。结论:复方槐花补骨脂酊联合NB-UVB治疗稳定期散发型白癜风疗效显著,安全。

Objective:To evaluate the efficacy and safety of tincture of compound Flos Sophorae and Fructus Posraleae in combination with NB-UVB for stable sporadic vitiligo.Methods:A total of 190 cases of stable sporadic vitiligo were randomly divided into the treatment and control groups.Both groups were treated with topical BaiXiao tincture,fluticasone propionate cream and NB-UVB for 6 months.But ethanol extracts of Flos Sophorae and Platycladus orientalis were added to BaiXiao tincture for the treatment group.The clinical efficacy was evaluated after 3-and 6-month treatments.Results:After 3-and 6-month treatments,the total effective rates in the treatment group were 58.76%,83.51%,respectively,while in control group were 41.94%,50.54%,respectively(X^2=5.38,23.47 respectively;P<0.05 for both time points).After 6-month treatments,cure rate was significantly higher in the treatment group than in the controls(45.36%vs.22.58%,X^2=10.95,P<0.01).No serious adverse event was observed in either group.Conclusion:Tincture of compound Flos Sophorae and Fructus Posraleae is safe and effective for stable sporadic vitiligo.