脉冲染料激光联合外用噻吗洛尔滴眼液治疗婴幼儿表浅型血管瘤疗效分析

Effect of Pulsed Dye Paser Combined with Timolol Eye Drops on Superficial Hemangioma in Infants

目的:观察脉冲染料激光联合外用噻吗洛尔滴眼液治疗婴幼儿表浅型血管瘤的疗效。方法:将36例血管瘤患儿随机分为三组,每组均为12例。观察组:给予脉冲染料激光治疗,之后外用噻吗洛尔滴眼液;对照Ⅰ组:单纯给予脉冲染料激光治疗,治疗方案及疗程同观察组;对照Ⅱ组:给予噻吗洛尔滴眼液治疗,用药方法及疗程同观察组。结果:观察组脉冲染料激光治疗次数为(2.57±0.90)次,瘤体平均消退时间(71.83±18.71)d,出现表浅瘢痕1例,无其他并发症;对照Ⅰ组激光治疗次数为(5.25±0.75)次,瘤体平均消退时间(141.33±17.78)d,出现表浅瘢痕2例;对照Ⅱ组瘤体平均消退时间为(162.08±16.64)d,无并发症发生。观察组激光治疗次数显著低于对照I组(P<0.05);治疗组瘤体消退时间明显短于对照Ⅰ组、对照Ⅱ组(P<0.05)。结论:采用脉冲染料激光联合外用噻吗洛尔滴眼液治疗婴幼儿血管瘤疗效优于单纯采用激光治疗和单纯外用噻吗洛尔滴眼液治疗。

Objective To observe the therapeutic effect of pulsed dye laser combined with external timolol eye drops in the treatment of superficial hemangioma in infants.Methods Thirty-six children with hemangioma were randomly divided into three groups,12 in each group.Observation group:pulsed dye laser treatment,followed by topical timolol eye drops;controlⅠgroup:pulsed dye laser treatment alone,treatment plan and course of treatment with observation group;controlⅡgroup:administration of timolol Eye liquid treatment,medication and treatment are the same as the observation group.Results In the combined treatment group,the number of pulsed dye laser treatment was 2.57±0.90 times,and the average time of the tumor was 71.83±18.71 days.The number of times of laser treatment in the pure laser controlⅠgroup was 5.25±0.75,and the average duration of resolution in the return visit was 141.33±17.78 days.Simple external thiamethoxam bisoprolol eye dropsⅡgroup,visit fade time 162.08±16.64 days on average,no complications occurred.The frequency of laser treatment in the combined treatment group was significantly less than that in the controlⅠgroup(P<0.05),and the difference was statistically significant.The regression time in the treatment group was significantly less than that in the controlⅠandⅡgroup(P<0.05),and the difference was statistically significant.Conclusion Pulsed dye laser combined with external timolol eye drops is more effective than laser and external timolol eye drops in treating infantile hemangioma.