恶性肿瘤中PD-L1表达与EB病毒感染相关性研究进展

Research Progress of Correlation between PD-L1 Expression and EBV Infection in Malignant Tumors

EB病毒(EBV)感染与多种恶性肿瘤如鼻咽癌、淋巴瘤、胃癌等密切相关。程序性细胞死亡配体1(PD-L1)是关键的负性共刺激分子,可负向调控免疫反应,有助于肿瘤细胞免疫逃逸,促进肿瘤发生发展。近年来,以PD-L1为靶点的免疫治疗取得了显著成效,成为肿瘤领域的研究热点。目前研究表明,在恶性肿瘤中EBV感染可以使PD-L1的表达上调,但由于PD-L1表达的调节机制错综复杂,需深入研究恶性肿瘤中EBV感染与PD-L1表达上调的相关机制,使PD-L1免疫检查点抑制剂成为肿瘤免疫治疗的有效途径。

Epstein-Barr virus( EBV) infection is closely related to various malignant tumors such as nasopharyngeal carcinoma,lymphoma,gastric cancer and so on. Programmed cell death-ligand 1( PD-L1) is an important negative costimulatory molecule,which can negatively regulate the immune response,contribute to the immune escape of tumor cells,and promote the development of tumor. In recent years,immunotherapy targeting PD-L1 has obtained remarkable achievements,and has become a hot topic in the tumor field. Current studies have shown that EBV infection can up-regulate the expression of PD-L1 in malignant tumors. Because the regulation mechanism of PD-L1 expression is complicated,it is necessary to study the mechanism of EBV infection and up-regulation of PD-L1 expression in malignant tumors,so as to make PD-L1 immunological checkpoint inhibitors an effective way for tumor immunotherapy.