TC和PC化疗方案在晚期卵巢癌术后患者中的效果及安全性比较

Comparison of Efficacy and Safety of TC and PC Chemotherapy Regimens in Patients with Advanced Ovarian Cancer

目的比较铂类联合紫杉醇(TC)和铂类联合环磷酰胺(PC)化疗方案在晚期卵巢癌术后患者中的效果及安全性。方法选取2013年1月至2015年1月大连医科大学附属第一医院收治的84例晚期卵巢癌患者为研究对象,依据化疗方法不同分为研究组和对照组,各42例。研究组行TC化疗方案,对照组行PC化疗方案。观察两组患者的临床疗效,治疗前后的血清学指标[甲胎蛋白(AFP)、糖类抗原125(CA125)]及生活质量(角色功能、情绪功能、社会功能)评分,不良反应及预后情况。结果研究组总有效率高于对照组[83.33%(35/42)比59.52%(25/42)](P<0.05)。治疗后两组AFP、CA125均低于治疗前,两组不同时点间比较差异有统计学意义(P<0.05)。治疗后两组患者角色功能、情绪功能、社会功能评分均高于治疗前,且研究组高于对照组(P<0.05),两组各指标组间、时点间、组间和时点间交互作用差异有统计学意义(P<0.05)。研究组胃肠道反应、白细胞降低以及脱发少于对照组(P<0.05)。结论晚期卵巢癌术后行TC化疗方案可提高治疗效果,改善患者生活质量,减少不良反应。

Objective To compare effect and safety of TC(platinum combined with paclitaxel)and PC(platinum combined with cyclophosphamide)chemotherapy in patients with advanced ovarian cancer.Methods Eighty-four patients with advanced ovarian cancer admitted to the First Affiliated Hospital of Dalian Medical University from Jan.2013 to Jan.2015 were enrolled.The patients were divided into a study group and a control group according to different chemotherapy methods,42 cases each.The study group underwent TC chemotherapy and the control group received a PC chemotherapy regimen.The clinical efficacy of the two groups was observed.Serological indicators[alphafetoprotein(AFP),carbohydrate antigen 125(CA125)]and quality of life(role function,emotional function,social function)scores,adverse reactions,prognosis were evaluated before and after treatment.Results The total effective rate in the study group was higher than that in the control group[83.33%(35/42)vs 59.52%(25/42)](P<0.05).After treatment,the AFP,CA125 of the two groups were lower than those before treatment,and there was significant difference between the two groups at different time points(P<0.05).Therole function,emotional function and social function scores of both groups after treatment were higher than before treatment,and the study group higher than the control group(P<0.05),and the differences between groups,time points and interactions of group and time point were statistically significant(P<0.05).The adverse reactions of gastrointestinal tract reaction,leukopenia and alopecia in the study group were less than those in the control group(P<0.05).Conclusion TC chemotherapy after surgery for advanced ovarian cancer can improve the treatment effect,improve the quality of life,reduce the adverse reactions.