丹参多酚酸盐联合布地奈德对慢性阻塞性肺疾病急性加重期氧化应激的影响

Effects of Salvianolic Acid Salt Combined with Budesonide on Oxidative Stress in AECOPD

目的:探讨丹参多酚酸盐联合布地奈德对慢性阻塞性肺疾病(chronic obstructive pulmonary diseaes,COPD)急性加重期氧化应激的影响。方法:将慢性阻塞性肺疾病急性加重期患者200例随机分为4组各50例,对照组(A组)给予常规治疗;布地奈德组(B组)在常规治疗基础上吸入布地奈德混悬液,8 mg/d;丹参多酚酸盐组(C组)在常规治疗基础上加用丹参多酚酸盐200 mg静脉滴注,1次/d;丹参多酚酸盐联合布地奈德组(D组)在常规治疗基础上加用丹参多酚酸盐200 mg静脉滴注,1次/d,吸入布地奈德混悬液,8 mg/d。治疗10天后观察各组患者血清丙二醛(MDA)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化酯(GSH-Px)变化情况。结果:B、C、D组患者血清中MDA含量低于A组(P<0.05),GSH-Px、SOD含量高于A组(P<0.05),其中D组最明显(P<0.01)。结论:丹参多酚酸盐联合布地奈德能降低COPD急性加重期患者MDA水平,提高GSH-Px、SOD含量。

Objective: To discuss the effects of salvianolic acid salt combined with budesonide on oxidative stress in acute exacerbation chronic obstructive pulmonary disease(AECOPD). Methods: All 200 patients were randomized into four groups, 50 cases each group, the control group(A) accepted conventional therapy;budesonide group(B) inhaled budesonide suspension based on conventional therapy, 8 mg each day;salvianolic acid salt group(C)accepted intravenous dripping of salvianolic acid salt based on conventional therapy, 200 mg, once each day;and the combination group(D) intravenous dripping of salvianolic acid salt based on conventional therapy, 200 mg, once each day, the inhalation of budesonide suspension, 8 mg each day. The changes of GSH-Px, SOD and MDA of the patients in different groups were observed after treating for ten days. Results: MDA contents of B, C and D were lower than these of A(P<0.05), while GSH-Px and SOD contents higher than these of A(P<0.05), among them,especially D notable(P<0.01). Conclusion: Salvianolic acid salt combined with budesonide could decrease the levels of MDA, raise the contents of GSH-Px and SOD in AECOPD patients.