微信公众号在降低多发性骨髓瘤患者使用硼替佐米皮下注射引起不良反应的应用

The application of WeChat public account in reducing adverse reactions induced by subcutaneous bortezomib injection in patients with multiple myeloma

目的探讨将微信公众号应用于多发性骨髓瘤患者使用硼替佐米皮下注射引起不良反应的医护工作中的实施效果。方法选取2017年9月~2018年12月解放军总医院第一医学中心血液病科收治的多发性骨髓瘤患者80例,随机数表法分为治疗组和对照组,每组40例,其中治疗组采用微信公众号对血液病科医护人员进行干预,比较两组多发性骨髓瘤患者使用硼替佐米皮下注射后,局部红肿、硬结、疼痛、神经毒性等不良反应的变化。结果治疗组的局部红肿、硬结发生率低于观察组,治疗组的疼痛缓解率高于观察组,差异具有统计学意义(P<0.05),两组神经毒性差异不具备统计学意义(P=0.1203)。结论将微信公众号应用到血液病科医护人员针对多发性骨髓瘤患者使用硼替佐米皮下注射的医护工作中,可降低局部红肿、硬结、疼痛、神经毒性等不良反应的发生率,对多发性骨髓瘤患者得到更好治疗有积极作用。

Objective To explore the effect of WeChat Public account in the treatment of adverse reactions caused by bortezomib subcutaneous injection in multiple myeloma patients.Methods About 80 patients admitted to the hematology department with multiple myeloma treated with bortezomib from September 2017 to December 2018 were divided into treatment group and control group randomly.And intervened using WeChat Public account was used in the treatment group but not in the control group.The changes of local redness,induration,pain,neurotoxicity and other adverse reactions were compared between the two groups after subcutaneous injection of bortezomib.Results The patient's local redlness and induration in treatment group were lower than those in the control group.The rate of pain relief from to treatment group was higher than that in the control group.The differences were statistically significant(P<0.05).The incidence of neurotoxicity of the two groups was not statistically significant in the difference(P=0.1203).Conclusion The application of WeChat public account in reducing adverse reactions induced by subcutaneous bortezomib injection in patients with multiple myeloma can reduce the incidence of local redness,induration,pain,neurotoxicity and other adverse reactions,and play a more effective role in treatment of multiple myeloma patients.