补肾活血化浊方治疗肝豆状核变性的Meta分析

Meta-analysis of Bushen Huoxue Huazhuo Decoction in the Treatment of Wilson’s Disease

目的分析补肾活血化浊方联合西药治疗肝豆状核变性的临床疗效。方法计算机检索1995年-2019年国内外发表的数据库中关于中补肾活血化浊方联合西药常规治疗(治疗组)和单用常规西药治疗(对照组)治疗肝豆状核变性的随机对照试验(randomized controlled trial,RCT)。Cochrane偏倚风险工具用于评估文献质量,RevMan5.3软件用于Meta分析。结果最终纳入8项RCT,共507例患者。Meta分析结果显示:与单纯西药治疗相比,补肾活血化浊方联合西药治疗方案可有效提高临床疗效(RR=1.34,95%CI:[1.20,1.49],P<0.00001),异质性检验I2=24%。结论中药补肾活血化浊方联合西药排铜治疗肝豆状变性能有效提高临床疗效。但因纳入的RCTs数量和质量限制,本结论仍需大样本、高质量的随机对照试验加以佐证。

Objective To evaluate the clinical efficacy of Wilson's disease Bushen Huoxue Huazhuo Co-western medicine.Methods We searched in 1995-2019 years has published database on the Bushen Huoxue Huazhuo Co-conventional western medicine treatment(treatment group)and conventional Western medicine treatment alone(control group)treatment of randomized controlled trials of Wilson's disease(randomized controlled trial,RCT).Cochrane risk of bias tool for assessing the quality of literature,RevMan5.3 software for Meta analysis.Results Finally,eight RCT,a total of 507 cases of patients.Meta analysis showed that:Compared with western medicine alone,Bushen Huoxue Huazhuo decoction combined with Western medicine can improve the clinical efficacy(RR=1.34,95%CI:[1.20,1.49],P<0.00001),the test for heterogeneity I2=24%.Conclusion Chinese medicine Bushen Huoxue Huazhuo Co-treatment of Wilson's copper discharge performance becomes effectively improve clinical outcomes.But the quantity and quality of RCTs included in the restrictions,this conclusion still need large samples,high-quality randomized controlled trials be corroborated.