硬膜外阻滞复合丙泊酚靶控输注对胃癌根治术患者血流动力学及脑电双频指数的影响

Effect of epidural block plus propofol target controlled infusion on hemodynamics and bispectral index in patients with radical gastrectomy

目的探讨硬膜外阻滞复合丙泊酚靶控输注(TCI)对胃癌根治术患者血流动力学及脑电双频指数(BIS)的影响。方法80例胃癌根治术患者随机分为观察组和对照组,分别采用硬膜外阻滞复合丙泊酚TCI、丙泊酚TCI。比较围手术期心率、平均动脉压(MAP)、BIS值及不良事件。结果观察组手术期间HR和MAP较平稳(P>0.05),而对照组波动明显(P<0.05)。观察组丙泊酚用量、BIS值明显低于对照组(P<0.05或0.01)。结论硬膜外阻滞复合丙泊酚TCI可使胃癌根治术患者的血流动力学更加平稳,并减少不良事件。

Objective To investigate the effect of epidural block plus propofol target controlled infusion(TCI)on hemodynamics and bispectral index(BIS)in patients with radical gastrectomy.Methods Eighty patients with radical gastrectomy randomly received propofol TCI with(observation group)or without(control group)epidural block.Perioperative heart rate(HR),mean arterial pressure(MAP),BIS values and adverse events were compared between two groups.Results Intraoperative HR and MAP were steady in observation group(P>0.05)and undulatory in control group(P<0.05).Propofol dose and BIS values were lower in observation group than in control group(P<0.05 or 0.01).Conclusion Epidural block plus propofol TCI can stabilize the hemodynamics and reduce the adverse events in patients with radical gastrectomy.