摘要
目的观察蔗糖铁对慢性射血分数中间值心力衰竭(HFmrEF)患者合并铁缺乏(ID)的疗效。方法90例慢性HFmrEF合并ID患者随机分为观察组和对照组,两组均给予常规抗心力衰竭治疗,观察组增加蔗糖铁静脉滴注。比较两组治疗半年后心功能级别、6 min步行距离、血红蛋白(Hb)、红细胞计数、N末端B型利钠肽原(NT-proBNP)水平、生活质量和不良事件情况。结果观察组治疗后心功能级别、NT-PROBNP水平、躯体状况评分、情绪状况评分、总体健康评分和因心力衰竭恶化住院率低于对照组(P<0.05),而6 min步行距离、Hb水平、红细胞计数高于对照组(P<0.05)。结论蔗糖铁可改善慢性HFmrEF合并ID患者的心功能、贫血、活动耐力和生活质量。
Objective To observe the clinical efficacy of iron sucrose in patients with chronic heart failure with midrange ejection fraction(HFmrEF)and iron deficiency(ID).Methods Ninety patients with chronic HFmrEF and ID were randomized to observation and control groups.In addition to routine anti-heart failure treatment,intravenous infusion of iron sucrose was added in observation group.Cardiac function,6-minute walking distance,levels of hemoglobin,erythrocytes and N-terminal pro-brain natriuretic peptide(NT-proBNP),quality of life and adverse events were compared between two groups after 0.5-year treatment.Results Compared with control group,heart function grading,NT-proBNP level,body condition score,emotional status score,overall health score and hospitalization rate due to heart failure deterioration were lower,while 6-minute walking distance,hemoglobin,erythrocytes were higher in observation group(P<0.05).Conclusion Iron sucrose can improve cardiac function,anemia,activity endurance,and quality of life in patients with chronic HFmrEF and ID.
作者
甄子英
黄俊豪
林子川
李劲维
ZHEN Zi-ying;HUANG Jun-hao;LIN Zi-chuan;LI Jin-wei(DepartmentⅠof Cardiology,Taishan People's Hospital,Taishan 529200,China)
出处
《广东医科大学学报》
2019年第5期563-566,共4页
Journal of Guangdong Medical University
基金
江门市卫生计生局科学技术研究项目(No.17A075)
关键词
射血分数中间值心力衰竭
蔗糖铁
铁缺乏
heart failure with midrange ejection fraction
iron sucrose
iron deficiency