银杏二萜内酯治疗进展性缺血性脑卒中的疗效及安全性分析

Analysis on curative effects and safety of ginkgo diterpene lactone in treatment of progressive ischemic stroke

目的探讨银杏二萜内酯治疗进展性缺血性脑卒中的疗效及安全性分析。方法选取2017年6月~2018年6月本院进展性缺血性脑卒中100例,依据随机数字表法分为常规组和给药组,每组50例,常规组给予常规对症治疗(电解质平衡、调脂以及降压等),给药组在此基础上给予银杏二萜内酯治疗,比较两组治疗疗效及安全性。结果两组治疗后NIHSS、MRS评分明显低于治疗前,给药组治疗后NIHSS、MRS评分明显低于常规组,差异有统计学意义(P<0.05);给药组治疗有效率明显高于常规组,差异有统计学意义(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论银杏二萜内酯可有效改善进展性缺血性脑卒中的神经功能损伤,有利于提高治疗疗效,且具有良好的安全性,值得临床推广。

Objective To explore curative effects and safety of ginkgo diterpene lactone in treatment of progressive ischemic stroke.Methods One hundred patients with progressive ischemic stroke in our hospital from June 2017 to June 2018 were selected.According to the random number table method,they were divided into the routine group and the medication group,with 50 cases in each group.The routine group was given routine symptomatic treatment(electrolyte balance,lipid regulation and lowering blood pressure,etc.)while the medication group was treated with ginkgo diterpene lactone on basis of it.Curative effects and safety of two groups were compared.Results NIHSS and MRS scores of the two groups after treatment were significantly lower than those before treatment.NIHSS and MRS scores after treatment of the medication group were significantly lower than those of the routine group.The difference was statistically significant(P<0.05).The effective rate of treatment in medication group was significantly higher than that in the routine group,and the difference was statistically significant(P<0.05).The adverse reactions of the two groups were basically the same,there was no significant difference between the two groups(P>0.05).Conclusion Ginkgo diterpene lactone can effectively improve the neurological impairment caused by progressive ischemic stroke.It is conducive to improving curative effects and it has good safety,which is worthy of clinical promotion.