不同手术方式治疗卵巢囊肿的效果及对患者免疫功能的影响比较

Comparison of curative effects of different surgical methods in treatment of ovarian cysts and its effect on immune function of patients

目的探讨临床中开腹卵巢囊肿剔除术和腹腔镜卵巢囊肿剔除术在治疗卵巢囊肿的手术效果和对患者免疫功能的影响。方法选取2017年6月~2018年7月四会市人民医院妇产科收治的卵巢囊肿患者68例,按照随机数字表法分为对照组和观察组,每组34例,对照组采用开腹卵巢囊肿剔除术,观察组患者采用腹腔镜卵巢囊肿剔除术,观察和比较两组患者的相关手术指标参数以及免疫功能相关指标的变化情况。结果与对照组相比,观察组中患者的术中出血量、排气时间、住院天数明显较少,差异有统计学意义(P<0.05);两组患者术后第1天的CD3+、CD4+、CD8+、CD4+/CD8+、NK细胞比例较术前1天均显著降低,差异有统计学意义(P<0.05);术后1天与对照组相比,观察组中的CD3+、CD4+、CD4+/CD8+、NK细胞免疫学指标的对应比例有明显的升高,差异有统计学意义(P<0.05)。结论临床中治疗良性卵巢囊肿,与开腹手术治疗相比,腹腔镜卵巢囊肿剔除术能够达到更显著的治疗效果,手术过程中对于患者的创伤更小,此外对人体免疫功能的损伤也较小,有很高的临床应用价值,值得大力推广。

Objective To explore surgical effects of open ovarian cyst removal and laparoscopic ovarian cyst removal in clinical treatment of ovarian cysts and its effect on immune function of patients.Methods 68 patients with ovarian cysts who were admitted and treated in department of obstetrics and gynecology in Sihui People’s Hospital from June 2017 to July 2018 were selected.According to the random number table method,they were divided into the control group and the observation group,with 34 cases in each group.The control group was given open ovarian cyst removal while the observation group was given laparoscopic ovarian cyst removal.The changes of surgical parameters and immune function related indexes in the two groups were observed and compared.Results Compared with the control group,intraoperation blood loss,exhaust time and hospital stay of the observation group were significantly less than those in the control group.The difference was statistically significant(P<0.05).In addition,the ratio of CD3+,CD4+,CD8+,CD4+/CD8+and NK cells on the first day after operation was significantly lower than that on the first day before operation between the two groups.The difference was statistically significant(P<0.05).On the first day after operation,the ratio of CD3+,CD4+,CD4+/CD8+and NK cells in the observation group was significantly higher than that in the control group.The difference was statistically significant(P<0.05).Conclusion Compared with open surgery,laparoscopic ovarian cyst removal in clinical treatment of ovarian cysts can achieve good clinical curative effects.It has less trauma to the patients during surgery and it has less damage to human immune function.It has high clinical application values,which is worth promotion.